777-93-5

Basic information

• Product Name: 5-(4-METHYLPHENYL)VALERIC ACID
• Synonyms: 5-(4-METHYLPHENYL)VALERIC ACID;4-METHYLPHENYLPENTANOIC ACID;5-(P-TOLYL)VALERIC ACID
• CAS NO: 777-93-5
• Molecular Formula: C₁₂H₁₆O₂
• Molecular Weight: 192.25
• Mol File: 777-93-5.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-METHYLPHENYL)VALERIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-METHYLPHENYL)VALERIC ACID(777-93-5)
• EPA Substance Registry System: 5-(4-METHYLPHENYL)VALERIC ACID(777-93-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 777-93-5(Hazardous Substances Data)

Upstream product

• 39928-72-8 5-chloromethyl-dihydro-furan-2-one 
• 108-88-3 toluene 
• 99857-43-9 1-bromo-4-(4'-methylphenyl)butane 
• 833-85-2 5-(4-methylphenyl)-5-oxopentanoic acid 
• 10544-63-5 ethyl crotonate 
• 104-87-0 4-methyl-benzaldehyde 
• 7446-70-0 aluminium trichloride 
• 624-31-7 4-tolyl iodide 
• 36440-63-8 ethyl 4-(4-methylphenyl)butanoate 
• 53392-07-7 4-(4-methylphenyl)butan-1-ol 
• 108-55-4 glutaric anhydride, 
• 17857-14-6 (3-carboxypropyl)(triphenyl)phosphonium bromide 
• 5724-05-0 5-(p-tolyl)pent-4-enoic acid 
• 591-80-0 pent-4-enoic acid 

Downstream Products

• 860574-72-7 5-p-tolyl-valeric acid amide 
• 1027282-87-6 1-Thiophen-2-yl-5-p-tolyl-pentan-1-one 
• 1027927-91-8 2-(5-p-Tolyl-pentyl)-thiophene 
• 1026001-90-0 3,3-Dimethyl-5-oxo-5-[5-(5-p-tolyl-pentyl)-thiophen-2-yl]-pentanoic acid 
• 1431329-92-8 C₄₃H₅₈N₂O₅ 
• 1431329-93-9 tert-butyl (5R,7S)-2,2-dimethyl-7-{1-methyl-5-[5-(4-methylphenyl)pentanoyl]-1H-pyrrol-2-yl}-3-oxa-1-azaspiro[4.4]nonane-1-carboxylate 
• 1322547-44-3 1-{5-[(1S,3R)-3-amino-3-(hydroxymethyl)cyclopentyl]-1-methyl-1H-pyrrol-2-yl}-5-(4-methylphenyl)pentan-1-one 
• 100388-65-6 5-(p-tolyl)pentanoyl chloride 

Relevant articles and documents

Cooperative iodine and photoredox catalysis for direct oxidative lactonization of carboxylic acids

A new method for the formation of γ- and δ-lactones from carboxylic acids through direct conversion of benzylic C-H to C-O bonds is described. The reaction is conveniently induced by visible light and relies on a mild cooperative catalysis by the combination of molecular iodine and an organic dye.

Pd-Catalyzed reductive heck reaction of olefins with aryl bromides for Csp2-Csp3 bond formation

We developed a Pd-catalyzed intermolecular reductive Heck reaction to construct Csp2-Csp3 bonds between aryl bromides and olefins. Various styrene derivatives, acyclic and cyclic alkenes, were well tolerated to couple with varied aryl bromides in linear selectivity. Kinetic and deuterium labeling experiments suggested that i-PrOH provides a hydride through β-H elimination.

Synthesis of (3S)-(tert-butyldimethylsilyloxy)methylcyclopentan-1-one as a key intermediate of sphingosine 1-phosphate-1 receptor agonists

Herein we report the asymmetric synthesis of (3S)-(tert- butyldimethylsilyloxy)methylcyclopentan-1-one (S)-3 as a practical chiral synthon for a wide range of pharmaceutical and/or natural products, using Lipshutz's asymmetric copper-catalyzed conjugate reduction. This method makes it feasible to prepare a conformationally constrained cyclopentane analogue 12, which is one of the key intermediates for the synthesis of novel sphingosine 1-phosphate-1 receptor agonists.