7803-49-8Relevant articles and documents
Divers, E.,Haga, T.
, p. 203 (1885)
Witt-Hurd, C. de,Brownstein, H. J.
, p. 67 (1925)
Electrocatalytic Multielectron Nitrite Reduction in Water by an Iron Complex
Stroka, Jesse R.,Kandemir, Banu,Matson, Ellen M.,Bren, Kara L.
, p. 13968 - 13972 (2020)
Catalytic reduction of nitrite by an iron complex in water near neutral pH to form hydroxylamine and ammonium is reported. The catalyst is an iron center coordinated by the pentadentate macrocycle 2,13-dimethyl-3,6,9,12,18-pentaazabicyclo[12.3.1]octadeca-1(18),2,12,14,16-pentaene (FeN5H2). Catalysis is observed by cyclic voltammetry at a half-wave potential of Ep/2 = -0.98 V vs Ag/AgCl (1 M KCl) when FeN5H2, nitrite, and a buffer (pH 7.2) are present. Controlled potential electrolysis of FeN5H2 and nitrite in pH 7.2 buffer at -0.98 V produces hydroxylamine (faradaic efficiency > 90%). FeN5H2 catalyzes ammonium production by disproportionation of hydroxylamine with concomitant formation of nitrous oxide and dinitrogen. These results are a rare example of multielectron electrocatalytic nitrite reduction by an iron complex near neutral pH.
THE FORMATION OF HYDROXYLAMINE BY INSERTION OF THE NH(1Δ) RADICAL INTO THE O-H BOND OF WATER
Kawai, Jun,Tsunashima, Shigeru,Sato, Shin
, p. 823 - 826 (1983)
The photolysis of hydrogen azide was examined in water.The main products were nitrogen and hydroxylamine.Hydroxylamine formed was converted into acetoxime by the reaction with acetone which was added after irradiation.The amount of acetoxime was analyzed
Versatility and trends in the interaction between Pd(ii) and peptide hydroxamic acids
Ozsváth, András,Farkas, Etelka,Diószegi, Róbert,Buglyó, Péter
, p. 8239 - 8249 (2019)
Primary and secondary di- and tripeptide hydroxamic acids, Ala-Ala-NHOH, Ala-Ala-N(Me)OH, Ala-Gly-Gly-NHOH and Ala-Gly-Gly-N(Me)OH were synthesized and their interaction with Pd(ii) (as a Pt(ii) model but with faster ligand exchange reactions) was studied in aqueous solution in the presence of the Cl- competitor ion by pH-potentiometric and 1H NMR methods. To the best of our knowledge, this is the first detailed solution study on Pd(ii)-peptide hydroxamate systems revealing that, except for Ala-Gly-Gly-NHOH, the other three ligands act not only as coordination compounds, but also the hydrolysis of the coordinated ligands and formation of the protonated hydroxylamine and Pd(ii) complexes of the corresponding peptides under acidic conditions occurred. The hydrolysis was rather slow with Ala-Gly-Gly-N(Me)OH (more than one week), and just a bit faster with Ala-Ala-NHOH, so speciation studies could also be performed successfully on the systems containing one of the latter two ligands. This was, however, hindered for the Pd(ii)-Ala-Ala-N(Me)OH system, where, in addition to the quite fast hydrolysis of the ligand, the reduction of Pd(ii) to elementary metal by the N(Me)-hydroxylamine formed was also observed. Speciation studies with Ala-Gly-Gly-NHOH revealed the predominance of a very stable 4N-donor complex, (NH2, 2Namide, Nhydr.) over a wide pH range. This ligand is also capable of binding the metal ion excess with the hydroxymate (O,O) set in dinuclear species. The formation of this latter type of complex is hindered with the secondary analogue, Ala-Gly-Gly-N(Me)OH, where, in addition to the 3N donor atoms, the hydroxamate-O is also involved in the coordination of the most stable complex. However, the formation of mixed hydroxo species at high pH and a bis-complex in a rather slow process with (NH2, Namide)2 bonding mode in the presence of ligand excess was proven. Although the 3N coordination (NH2, Namide, Nhydx) results in a highly stable complex with the dipeptide derivative, Ala-Ala-NHOH, the fourth coordination site remains free for accepting an NH2 moiety from the excess ligand, or a hydroxide ion at high pH. Likewise, the hydroxymate (O,O) set remains free to bind the metal ion excess in a trinuclear species. The results of this study may also contribute to the design and synthesis of novel Pt(ii) complexes with anticancer potential.
Polizzi, S.,Benedetti, A.,Fagherazzi, G.,Goatin, C.,Strozzi, R.,et al.
, p. 494 - 499 (1987)
Application of an immobilized ionic liquid for the preparation of hydroxylamine via hydrolysis of cyclohexanone oxime
Wang, Shuangyu,Liu, Jiaqi,Cheng, Peng,Li, Zhihui,Zhang, Dongsheng,Yang, Qiusheng,Zhao, Xinqiang,Wang, Yanji
, p. 742 - 750 (2021/02/05)
Preparation of hydroxylamine via hydrolysis of cyclohexanone oxime was studied over porous SiO2 supported acid ionic liquid catalyst. The catalyst [SPIPTES]CF3SO3@SiO2 was prepared through sol-gel method and characterized by elemental analysis, IR and TG, etc. Various parameters such as reaction temperature and time, catalyst amount were investigated systematically. The optimized reaction conditions investigated were catalyst:cyclohexanone oxime (mass ratio) 4 : 1, conducted at 60 °C for 1 h. Since the present hydrolysis reaction is controlled by thermodynamics, the conversion of cyclohexanone oxime could not be very high. However, reasonable result was achieved under the optimized reaction conditions. Cyclohexanone oxime conversion was 38.41 % and NH2OH yield was 37.65 %. Additionally, combining experiments with density functional theory calculations, a possible catalyst structure and reaction pathway involved protonated cyclohexanone oxime mechanism was proposed for the present hydrolysis in this study.
INHIBITORS OF RNA-BINDING PROTEINS, COMPOSITIONS THEREOF, AND THERAPEUTIC USES THEREOF
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Paragraph 0109, (2020/12/11)
The present technology is directed to compounds that inhibit of the interaction of RNA-binding protiens with RNA, intermediaes thereof, compositions thereof, and methods of treatment utilizing such compounds, where the compounds are of Formula (I).
