78205-48-8

Basic information

• Product Name: methyl 1-[2-amino-9-(4-hydroxy-2-methoxycarbonyl-pyrrolidine-1-carbonyl)-4,6-dimethyl-3-oxo-phenoxazine-1-carbonyl]-4-hydroxy-pyrrolidine-2-carboxylate
• CAS NO: 78205-48-8
• Molecular Formula: C₂₈H₃₀N₄O₁₀
• Molecular Weight: 582.567
• Mol File: 78205-48-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 819.7°Cat760mmHg
• Flash Point: 449.5°C
• Density: 1.61g/cm³
• CAS DataBase Reference: methyl 1-[2-amino-9-(4-hydroxy-2-methoxycarbonyl-pyrrolidine-1-carbonyl)-4,6-dimethyl-3-oxo-phenoxazine-1-carbonyl]-4-hydroxy-pyrrolidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-[2-amino-9-(4-hydroxy-2-methoxycarbonyl-pyrrolidine-1-carbonyl)-4,6-dimethyl-3-oxo-phenoxazine-1-carbonyl]-4-hydroxy-pyrrolidine-2-carboxylate(78205-48-8)
• EPA Substance Registry System: methyl 1-[2-amino-9-(4-hydroxy-2-methoxycarbonyl-pyrrolidine-1-carbonyl)-4,6-dimethyl-3-oxo-phenoxazine-1-carbonyl]-4-hydroxy-pyrrolidine-2-carboxylate(78205-48-8)

Safety Data

• Hazardous Substances Data: 78205-48-8(Hazardous Substances Data)

Upstream product

• 40126-30-5 (S)-4-Hydroxy-pyrrolidine-2-carboxylic acid methyl ester, hydrochloride 

Relevant articles and documents

Studies on Anticancer Agents: Synthesis of Some Anthramycin Analogs and Actinocinyl Diamides

9,11-Dihydroxy-8-methyl-2,3,5,10,11,11a-hexahydro-1H-pyrrolobenzodiazepine (11) and actinocinyldipyrrolidines (4 and 5) have been synthesized starting from 3-benzyloxy-4-methyl-2-nitrobenzamides (2 and 3).Catalytic hydrogenation of 2 and 3 followed by oxidative dimerisation affords actinocinyldipyrrolidines ( 4 and 5).Ethyl 1-(3-benzyloxy-4-methyl-2-nitrobenzoyl)-L-prolinate (2) on reduction, followed by acid-catalysed cyclisation, hydrogenolysis, protection of the o-aminophenol functionality by preparing benzylidien derivative, NaBH4 reduction and deblocking gives required pyrrolobenzodiazepine (11).