78318-43-1

Basic information

• Product Name: 4-AMINO-2-MORPHOLINO-5-PYRIMIDINECARBONITRILE, 97
• Synonyms: 4-Amino-2-(4-morpholinyl)-5-pyrimidinecarbonitrile;4-AMINO-2-MORPHOLINO-5-PYRIMIDINECARBONITRILE, 97
• CAS NO: 78318-43-1
• Molecular Formula: C₉H₁₁N₅O
• Molecular Weight: 205.22
• Mol File: 78318-43-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 232-233℃
• Boiling Point: 490.7 °C at 760 mmHg
• Flash Point: 250.6 °C
• Appearance: /
• Density: 1.37
• PKA: 5.15±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-2-MORPHOLINO-5-PYRIMIDINECARBONITRILE, 97(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2-MORPHOLINO-5-PYRIMIDINECARBONITRILE, 97(78318-43-1)
• EPA Substance Registry System: 4-AMINO-2-MORPHOLINO-5-PYRIMIDINECARBONITRILE, 97(78318-43-1)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Safety Statements: S36/37:Wear suitable protective clothing and gloves.
• Hazardous Substances Data: 78318-43-1(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of Heterocyclic Chemistry, 24, p. 1305, 1987 DOI: 10.1002/jhet.5570240514

Upstream product

• 110-91-8 morpholine 
• 94741-69-2 4-amino-2-chloropyrimidine-5-carbonitrile 
• 5638-78-8 morpholinoformamidine hydrochloride 
• 123-06-8 Ethoxymethylenemalononitrile 
• 98198-13-1 4-amino-2-methanesulfonyl-pyrimidine-5-carbonitrile 
• 770-30-9 4-amino-2-(methylthio)pyrimidine-5-carbonitrile 
• 113411-64-6 3-Cyanamino-2-cyanopropenenitrile sodium salt 

Downstream Products

• 918662-89-2 N-(5-cyano-2-morpholin-4-yl-pyrimidin-4-yl)-benzamide 

Relevant articles and documents

SUSTITUTED ( HETEROARYLMETHYL ) THIOHYDANTOINS AS ANTICANCER DRUGS

The invention relates to substituted (heteroarylmethyl) thiohydantoin compounds of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, and their use for the preparation of medicaments for the treatment and/or prophylaxis of disorders, in particular of prostate cancer.

A Convenient Synthesis of 2-Substituted 4-Amino-5-pyrimidinecarbonitriles

Synthesis of the novel 2-halogenated 4-amino-5-pyrimidinecarbonitriles 3a,b starting from ethoxymethylenemalononitrile 1 and cyanamide is described.Nucleophilic substitution of the reactive halogen atom leads to the derivatives 5a-g,6 and 7a-h.