94741-69-2

Basic information

• Product Name: 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE
• Synonyms: 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE;4-AMINO-2-CHLORO-5-PYRIMIDINECARBONITRILE;BUTTPARK 60\40-60;4-AMINO-2-CHLOROPYRIMIDINE-5-CARBOXNITR&;4-Amino-2-chloropyrimidine-5-carbonitrile ,97%;4-Amino-2-chloropyrimidine-5-carbonitrile , Tech.;5-PyriMidinecarbonitrile, 4-aMino-2-chloro-
• CAS NO: 94741-69-2
• Molecular Formula: C₅H₃ClN₄
• Molecular Weight: 154.56
• Product Categories: Pyrimidine;Heterocyclic Compounds;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Pyrimidines;PyrimidinesHeterocyclic Building Blocks;Building Blocks;C4 to C5;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks;Heterocycle-Pyrimidine series
• Mol File: 94741-69-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 200 °C (dec.)(lit.)
• Boiling Point: 435.047 °C at 760 mmHg
• Flash Point: 216.909 °C
• Appearance: /Powder or Flakes
• Density: 1.538 g/cm³
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DMF, DMSO, Methanol, Water
• PKA: -0.68±0.10(Predicted)
• CAS DataBase Reference: 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE(94741-69-2)
• EPA Substance Registry System: 4-AMINO-2-CHLOROPYRIMIDINE-5-CARBONITRILE(94741-69-2)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41-43
• Safety Statements: 26-36/37/39
• RIDADR: UN3439
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 94741-69-2(Hazardous Substances Data)

Usage

Description

4-Amino-2-chloropyrimidine-5-carbonitrile is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical agents. It is characterized by the presence of an amino group, a chloro substituent, and a carbonitrile group attached to a pyrimidine ring. This unique structure endows it with versatile reactivity and potential applications in medicinal chemistry.

Uses

Used in Pharmaceutical Industry:
4-Amino-2-chloropyrimidine-5-carbonitrile is used as a potential substituent in the synthesis of anti-anxiety, anti-depressant, and anti-psychotic agents. Its presence in these compounds allows for the modulation of neurotransmitter levels and the regulation of mood, providing therapeutic benefits for individuals suffering from anxiety, depression, and other mental health disorders.
In the synthesis of these agents, 4-amino-2-chloropyrimidine-5-carbonitrile can be incorporated into various molecular frameworks, enabling the development of novel drugs with improved efficacy, selectivity, and safety profiles. Its reactivity and structural features make it a valuable building block for medicinal chemists working on the design and optimization of new therapeutic agents for mental health conditions.

Upstream product

• 113411-64-6 3-Cyanamino-2-cyanopropenenitrile sodium salt 
• 3177-24-0 2,4-dichloropyrimidine-5-carbonitrile 

Downstream Products

• 90973-23-2 4-amino-2-piperidin-1-yl-pyrimidine-5-carbonitrile 
• 78318-43-1 4-Amino-2-morpholino-pyrimidin-5-carbonitril 
• 6964-55-2 4-amino-2-methoxy-pyrimidine-5-carbonitrile 
• 94742-00-4 4-Amino-2-ethoxy-pyrimidine-5-carbonitrile 
• 94741-64-7 4-Amino-2-decyloxy-pyrimidine-5-carbonitrile 
• 94741-65-8 4-Amino-2-hexadecyloxy-pyrimidine-5-carbonitrile 
• 113411-73-7 Methyl 2<4-(4-amino-5-cyanopyrimidyl-2-oxy)phenoxy>propionate 
• 113411-66-8 4-Amino-2-(4-methoxy-phenoxy)-pyrimidine-5-carbonitrile 
• 113411-65-7 4-Amino-2-phenoxy-pyrimidine-5-carbonitrile 
• 113447-04-4 4-Amino-2-(4-chloro-phenoxy)-pyrimidine-5-carbonitrile 
• 113411-69-1 4-Amino-2-isobutylamino-pyrimidine-5-carbonitrile 
• 113411-67-9 4-Amino-2-(4-bromo-phenoxy)-pyrimidine-5-carbonitrile 
• 113411-68-0 4-Amino-2-(4-cyano-phenoxy)-pyrimidine-5-carbonitrile 
• 16357-69-0 4-amino-5-cyanopyrimidine 

Relevant articles and documents

PYRIMIDINE OR PYRIDINE DERIVATIVES USEFUL AS PI3K INHIBITORS

Compounds (I) and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including P13 kinase activity, are described herein.

A Convenient Synthesis of 2-Substituted 4-Amino-5-pyrimidinecarbonitriles

Synthesis of the novel 2-halogenated 4-amino-5-pyrimidinecarbonitriles 3a,b starting from ethoxymethylenemalononitrile 1 and cyanamide is described.Nucleophilic substitution of the reactive halogen atom leads to the derivatives 5a-g,6 and 7a-h.