78495-95-1

Basic information

• Product Name: 2-Propenal, 3-(4-fluorophenyl)-2-Methyl-
• Synonyms: 2-Propenal, 3-(4-fluorophenyl)-2-Methyl-
• CAS NO: 78495-95-1
• Molecular Formula: C10H9FO
• Molecular Weight: 164.1762632
• Mol File: 78495-95-1.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-Propenal, 3-(4-fluorophenyl)-2-Methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propenal, 3-(4-fluorophenyl)-2-Methyl-(78495-95-1)
• EPA Substance Registry System: 2-Propenal, 3-(4-fluorophenyl)-2-Methyl-(78495-95-1)

Safety Data

• Hazardous Substances Data: 78495-95-1(Hazardous Substances Data)

Usage

Main properties

1. Chemical formula: C11H9FO
2. Derivative of propenal (acrolein)
3. Contains a 4-fluorophenyl group and a methyl group

Specific content

1. Highly reactive and pungent-smelling liquid
2. Potentially useful in pharmaceutical or agrochemical applications
3. Toxic and known to cause irritation to eyes, skin, and respiratory system
4. Ongoing studies on potential hazards and uses

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 123-38-6 propionaldehyde 
• 134294-41-0 ethyl 3-(4-fluorophenyl)-2-methyl-2-propenoate 
• 462-06-6 fluorobenzene 
• 78-84-2 isobutyraldehyde 
• 1000995-66-3 (E)-3-(4-fluorophenyl)-2-methylprop-2-en-1-ol 

Relevant articles and documents

Asymmetric Nazarov Cyclizations of Unactivated Dienones by Hydrogen-Bond-Donor/Lewis Acid Co–Catalyzed, Enantioselective Proton-Transfer

We report an enantioselective Nazarov cyclization catalyzed by chiral hydrogen-bond-donors in concert with silyl Lewis acids. The developed transformation provides access to tri-substituted cyclopentenones in high levels of enantioselectivity (up to 95% e.e.) from a variety of simple unactivated dienones. Kinetic and mechanistic studies are consistent with a reversible 4π-electrocyclization C?C bond-forming step followed by rate- and enantio-determining proton-transfer as the mode of catalysis. (Figure presented.).

Dehydrogenative β-Arylation of Saturated Aldehydes Using Transient Directing Groups

An unprecedented cross-dehydrogenative-coupling (CDC) reaction of saturated aldehyde β-C-H with arenes to form cinnamaldehydes via the cleavages of four C-H bonds has been developed. The reaction possesses complete E-stereoselectivity for the C=C double bond. The protocol is featured by atom and step economy, mild reaction conditions, and convenient operation.

INHIBITORS OF HUMAN TUMOR-EXPRESSED CCXCKR2

Pharmaceutical compositions containing organic compounds or salts thereof that serve as modulators for the SDF-1 or I-TAC chemokines are disclosed. The compounds and compositions are useful in the treatment of cancer, especially in the inhibition of cancer proliferation, growth, and metastasis. Methods of interfering with SDF-1 and/or I-TAC binding to the CCXCKR2 receptor and treating cancer using the compounds and pharmaceutical compositions of the present invention are also disclosed.