78644-78-7

Basic information

• Product Name: N-(4-methoxyphenyl)pyridin-2-amine
• CAS NO: 78644-78-7
• Molecular Formula: C₁₂H₁₂N₂O
• Molecular Weight: 200.24
• Mol File: 78644-78-7.mol
• Article Data: 47

Chemical Properties

• Boiling Point: 340.2°Cat760mmHg
• Flash Point: 159.5°C
• Density: 1.159g/cm³
• CAS DataBase Reference: N-(4-methoxyphenyl)pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxyphenyl)pyridin-2-amine(78644-78-7)
• EPA Substance Registry System: N-(4-methoxyphenyl)pyridin-2-amine(78644-78-7)

Safety Data

• Hazardous Substances Data: 78644-78-7(Hazardous Substances Data)

Upstream product

• 109-09-1 2-chloropyridine 
• 104-94-9 4-methoxy-aniline 
• 109-04-6 2-bromo-pyridine 
• 15103-48-7 pyridine-2-sulfonic acid 
• 623-12-1 4-chloromethoxybenzene 
• 40825-17-0 Natrium-Verbindung des [2]Pyridylamins 
• 504-29-0 2-aminopyridine 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 696-62-8 para-iodoanisole 
• 66107-29-7 4-methoxyphenyl triflate 
• 15009-91-3 2-nitropyridine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 694-59-7 pyridine N-oxide 
• 459-64-3 4-methoxybenzenediazonium tetrafluoroborate 

Downstream Products

• 188836-21-7 [(4‐methoxy‐N‐(pyridin‐2‐ylmethyl)aniline)PdCl₂] 
• 82564-29-2 4-(N-pyridin-2-ylamino)phenol 
• 1206970-13-9 N-(4-(3-chloropyrazin-2-yloxy)phenyl)pyridin-2-amine 
• 1231921-88-2 N-(4-((3-(4-morpholinyl)-2-pyrazinyl)oxy)phenyl)-2-pyridinamine 
• 123444-29-1 8-hydroxypyrido[1,2-a]benzimidazole 
• 1613148-88-1 N-(4-methoxy-2-nitrophenyl)pyridin-2-amine 
• 1383232-09-4 N-(4-methoxyphenyl)-N-methyl-2-aminopyridine 

Relevant articles and documents

In Situ Formation of Cationic π-Allylpalladium Precatalysts in Alcoholic Solvents: Application to C-N Bond Formation

We report an efficient Buchwald-Hartwig cross-coupling reaction in alcoholic solvent, in which a low catalyst loading showed excellent performance for coupling aryl halides (I, Br, and Cl) with a broad set of amines, amides, ureas, and carbamates under mild conditions. Mechanistically speaking, in a protic and polar medium, extremely bulky biarylphosphine ligands interact with the dimeric precatalyst [Pd(π-(R)-allyl)Cl]2 to form the corresponding cationic complexes [Pd(π-(R)-allyl)(L)]Cl in situ and spontaneously. The resulting precatalyst further evolves under basic conditions into the corresponding L-Pd(0) catalyst, which is commonly employed for cross-coupling reactions. This mechanistic study highlights the prominent role of alcoholic solvents for the formation of the active catalyst.

COMPOUND FOR ORGANIC ELECTRONIC ELEMENT, ORGANIC ELECTRONIC ELEMENT USING THE SAME, AND AN ELECTRONIC DEVICE THEREOF

The present invention provides a novel compound capable of improving light emitting efficiency, stability and lifespan of an element, an organic electric element using the same, and an electronic device thereof.

Tunable Electrochemical C?N versus N?N Bond Formation of Nitrogen-Centered Radicals Enabled by Dehydrogenative Dearomatization: Biological Applications

Herein, an environmentally friendly electrochemical approach is reported that takes advantage of the captodative effect and delocalization effect to generate nitrogen-centered radicals (NCRs). By changing the reaction parameters of the electrode material and feedstock solubility, dearomatization enabled a selective dehydrogenative C?N versus N?N bond formation reaction. Hence, pyrido[1,2-a]benzimidazole and tetraarylhydrazine frameworks were prepared through a sustainable transition-metal- and exogenous oxidant-free strategy with broad generality. Bioactivity assays demonstrated that pyrido[1,2-a]benzimidazoles displayed antimicrobial activity and cytotoxicity against human cancer cells. Compound 21 exhibited good photochemical properties with a large Stokes shift (approximately 130 nm) and was successfully applied to subcellular imaging. A preliminary mechanism investigation and density functional theory (DFT) calculations revealed the possible reaction pathway.