66107-29-7Relevant articles and documents
Ni-Catalyzed Cross-Electrophile Coupling of Aryl Triflates with Thiocarbonates via C-O/C-O Bond Cleavage
Zhu, Zhaodong,Gong, Yuxin,Tong, Weiqi,Xue, Weichao,Gong, Hegui
supporting information, p. 2158 - 2163 (2021/04/05)
A nickel-catalyzed reductive coupling of aryl triflates with thiocarbonates is reported here. Both electron-rich and -deficient aryl C(sp2)-O electrophiles as well as a class of O-tBu S-alkyl thiocarbonates are compatible with the optimized reaction conditions, as evidenced by 49 examples. The reaction also proceeds with good chemoselective cleavage of the C-O bond with regard to thioesters. This work broadens the scope of nickel-catalyzed reductive cross-electrophile coupling reactions.
C(sp3) -C(sp2) Method for constructing key and β - aryl amino acid preparation method
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Paragraph 0037-0038; 0046, (2021/10/27)
The invention provides C. (sp3) - C(sp2) A method for constructing a key and β -aryl amino acid relates to the technical field of chemical substance synthesis and transition metal application, which comprises β-C amino acid. (sp3) Ring carbon C in place of phenolic hydroxyl group(sp2) A method of constructing C-C keys by direct coupling. The process will contain inactive β-C. (sp3) Amino acids of - H and ligands L of specific structure1 The tetradentate chelate is generated by complexation with bivalent nickel, and the amino acid labile β-C is completed under the catalysis of palladium with phenolic ester under basic conditions. (sp3) - H Aryl, proton transfer and the like are reacted to achieve C. (sp3) - C(sp2) Construction of a bond, finally hydrolytically releasing β-C aryl amino acid and ligand L1 C. (sp3) - C(sp2) The key construction method is simple and convenient to operate. The method has the advantages of low cost, strong reaction universality, high yield and stereoselectivity. The synthetic method provides a novel method for preparing various non-natural β - aryl amino acids, and provides a novel method for amino acidification/peptide modification of phenolic compounds with biological activity, and provides a novel approach and selection for the design and synthesis of new drugs.
Nickel-Catalyzed Arylation/Alkenylation of tert-Cyclobutanols with Aryl/Alkenyl Triflates via a C - C Bond Cleavage
Wang, Zhen,Hu, Yuanyuan,Jin, Hongwei,Liu, Yunkui,Zhou, Bingwei
, p. 466 - 474 (2020/12/22)
Herein, we first present a nickel-catalyzed arylation and alkenylation of tert-cyclobutanols with aryl/alkenyl triflates via a C-C bond cleavage. An array of γ-substituted ketones was obtained in moderate-to-good yields, thus featuring earth-abundant nick
