78667-04-6

Basic information

• Product Name: 2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE
• Synonyms: 2-CHLOROMETHYL-1-METHYL-1H-IMIDAZOLE HCL;2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE;1-Methyl-2-(chloromethyl)imidazole hydrochloride;2-(Chloromethyl)-1-methylimidazole hydrochloride;1H-IMidazole,2-(chloroMethyl)-1-Methyl-, hydrochloride (1:1)
• CAS NO: 78667-04-6
• Molecular Formula: C₅H₇ClN₂*ClH
• Molecular Weight: 167.04
• Mol File: 78667-04-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 175 °C
• Boiling Point: 243.7 °C at 760 mmHg
• Flash Point: 101.2 °C
• Appearance: /
• Vapor Pressure: 0.0493mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE(78667-04-6)
• EPA Substance Registry System: 2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE(78667-04-6)

Safety Data

• Hazard Codes: C:Corrosive
• Statements: R34:Causes burns.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36/37/39:Wear suitabl
• Hazardous Substances Data: 78667-04-6(Hazardous Substances Data)

Usage

General Description

2-(Chloromethyl)-1-methyl-1H-imidazole hydrochloride is a chemical compound with the molecular formula C5H7Cl2N2. 2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE is part of the imidazole family, which is a group of organic compounds notable for their five member ring structure, composed of three carbon atoms and two nitrogen atoms. 2-(CHLOROMETHYL)-1-METHYL-1H-IMIDAZOLE HYDROCHLORIDE plays a role in biochemistry and is often used in the synthesis of other products. Its hydrochloride category suggests it likely conducts hydrochloric acid when dissolved in water. It's important to handle this compound with care, as its effects on human health are not extensively studied.

InChI:InChI=1/C5H7ClN2.ClH/c1-8-3-2-7-5(8)4-6;/h2-3H,4H2,1H3;1H

Upstream product

• 17334-08-6 1-methyl-2-hydroxymethylimidazole 
• 13750-81-7 N-methyl-2-imidazolcarboxaldehyde 

Downstream Products

• 3984-53-0 2-Cyanmethyl-1-methyl-imidazol 
• 98991-30-1 N-methyl-2-<(benzylmercapto)methyl>imidazole hydrochloride 
• 189144-44-3 Dithiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2-cyano-ethyl) ester S-(1-methyl-1H-imidazol-2-ylmethyl) ester 
• 189153-32-0 Thiophosphoric acid O-[(2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl] ester O'-(2-cyano-ethyl) ester S-(1-methyl-1H-imidazol-2-ylmethyl) ester 
• 136609-17-1 2-[(1-methylimidazol-2-yl)methylthio]-4,5-diphenylimidazole 
• 267431-28-7 1-methyl-2-[(2-nitrophenoxy)methyl]-1H-imidazole 
• 864911-13-7 N-methyl-N-[4-({(1-methyl-1H-imidazol-2-ylmethyl)-[1-(toluene-4-sulfonyl)-1H-imidazol-2-ylmethyl]-amino}-methyl)-benzyl]-N',N'-dipropyl-butane-1,4-diamine 
• 1025771-48-5 (R)-N-(4-chloro-3-((1-methyl-1H-imidazol-2-yl)methoxy)benzyl)-1-(3-chlorophenyl)ethanamine 
• 1191102-70-1 ethyl 7-[(1-methyl-1H-imidazol-2-yl)methoxy]-5-[4-(methylsulfonyl)phenoxy]-1H-indole-2-carboxylate 
• 1318776-57-6 Methyl-4-((1-methyl-1H-imidazol-2-yl)methoxy)benzoate 
• 1449513-38-5 C₁₇H₂₄N₂O 

Relevant articles and documents

Nickel-Catalyzed Reversible Functional Group Metathesis between Aryl Nitriles and Aryl Thioethers

We describe a new functional group metathesis between aryl nitriles and aryl thioethers. The catalytic system nickel/dcype is essential to achieve this fully reversible transformation in good to excellent yields. Furthermore, the cyanide- and thiol-free reaction shows high functional group tolerance and great efficiency for the late-stage derivatization of commercial molecules. Finally, synthetic applications demonstrate its versatility and utility in multistep synthesis.

Efficient 'one-pot' methodology for the synthesis of novel tetrahydro-β-carboline, tetrahydroisoquinoline and tetrahydrothienopyridine derivatives

A simple and efficient 'one-pot' methodology was developed to generate a new series of tetrahydro-β-carboline (THBC), tetrahydroisoquinoline (THIQ) and tetrahydrothienopyridine (THTP) derivatives. The key step of the methodology is based on a Pictet-Spengler type cyclization of a reactive N-carbamyliminium ion. This methodology was applied to the synthesis of a library of 32 compounds with potential anti-tumoral activity.

Investigation of carbon-2 substituted imidazoles and their corresponding ionic liquids

The functionality at the C-2 position of the imidazole ring plays a key role in defining the chemical properties of the imidazoles and their corresponding ionic liquids. Imidazoles 1-6 with different C-2 functionality were synthesized and their corresponding ionic liquids were systematically investigated. Based on their physical properties the six imidazoles can be divided into three groups. (1) The imidazoles 2 and 3 are capable of self-polymerization to form poly(ionic liquid)s, and they are characterized with a strong leaving group at the C-2 position. (2) The imidazoles 4 and 5 can form ionic liquids, but they are very sensitive to moisture. (3) The imidazoles 1 and 6 can form stable ionic liquids, and their stabilities were influenced by the electronic effects of the substituents at the C-2 position.