78868-26-5

Basic information

• Product Name: {4-[(E)-3-(4-Fluoro-phenyl)-acryloyl]-phenyl}-acetic acid
• CAS NO: 78868-26-5
• Molecular Weight: 284.287
• Mol File: 78868-26-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: {4-[(E)-3-(4-Fluoro-phenyl)-acryloyl]-phenyl}-acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: {4-[(E)-3-(4-Fluoro-phenyl)-acryloyl]-phenyl}-acetic acid(78868-26-5)
• EPA Substance Registry System: {4-[(E)-3-(4-Fluoro-phenyl)-acryloyl]-phenyl}-acetic acid(78868-26-5)

Safety Data

• Hazardous Substances Data: 78868-26-5(Hazardous Substances Data)

Upstream product

• 7398-52-9 4-acetyl-phenylacetic acid 
• 459-57-4 4-fluorobenzaldehyde 

Downstream Products

• 78868-49-2 {4-[5-(4-Fluoro-phenyl)-isoxazol-3-yl]-phenyl}-acetic acid methyl ester 
• 78868-41-4 {4-[5-(4-Fluoro-phenyl)-isoxazol-3-yl]-phenyl}-acetic acid 
• 78868-33-4 {4-[2,3-Dibromo-3-(4-fluoro-phenyl)-propionyl]-phenyl}-acetic acid 

Relevant articles and documents

Anti-inflammatory Agents: Part IV - Synthesis and Anti-inflammatory Activity of 4-(5-Arylisoxazol-3-yl)phenylalkanoic Acids and Their Methyl Esters

The methyl esters (8a-d and 9a-d) of 4-(5-arylisoxazol-3-yl)phenylacetic and -phenyl-α-methylacetic acids (6a-d and 7a-d) have been synthesized from the corresponding chalkone dibromides (4a-d and 5a-d) by treatment with NH2OH.HCl in NaOH, followed by esterification of acids thus obtained.The anti-inflammatory activity of 6-9 has been evaluated.The most active compound 4-(5-phenylisoxazol-3-yl)phenyl-α-methylacetic acid (7a) showing 48.68percent inhibition is equipotent with phenylbutazone, but inactive in adjuvent induced arthritis test.