78999-61-8Relevant articles and documents
Pyrimidine Derivatives and Related Compounds. Part 48. Uracil Ring Transformation: Conversion of 5-Nitrouracils into 5-Carbamoyluracils
Hirota, Kosaku,Kitade, Yukio,Senda, Shigeo
, p. 1859 - 1861 (2007/10/02)
1,3-Disubstituted 5-nitrouracils (1) react with malonamide in ethanolic sodium ethoxide to afford 1-substituted 5-carbamoyluracils (3) via rearrangement of the N(3)-C(4)-C(5) portion of the uracil.This ring transformation has been applied to the preparation of 2',3',5'-tri-O-acetyl-5-carbamoyluridine (8).