79004-62-9

Basic information

• Product Name: 2-Propen-1-one, 1,3-bis(2,4-dimethoxyphenyl)-, (2E)-
• CAS NO: 79004-62-9
• Molecular Formula: C19H20O5
• Molecular Weight: 328.365
• Mol File: 79004-62-9.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1,3-bis(2,4-dimethoxyphenyl)-, (2E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1,3-bis(2,4-dimethoxyphenyl)-, (2E)-(79004-62-9)
• EPA Substance Registry System: 2-Propen-1-one, 1,3-bis(2,4-dimethoxyphenyl)-, (2E)-(79004-62-9)

Safety Data

• Hazardous Substances Data: 79004-62-9(Hazardous Substances Data)

Upstream product

• 829-20-9 2',4'-dimethoxyacetophenone 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 20469-63-0 1-iodo-2,4-dimethoxybenzene 
• 67756-04-1 1-(2,4-dimethoxy-phenyl)-prop-2-en-1-one 
• 84323-17-1 (2,4-Dimethoxy-phenyl)-{(2S,6R)-6-(2,4-dimethoxy-phenyl)-2-[2-(3,5-dimethoxy-phenyl)-6-methoxy-benzofuran-5-yl]-4-methyl-cyclohex-3-enyl}-methanone 
• 75629-26-4 8-[(1S,5R,6S)-6-(2,4-Dimethoxy-benzoyl)-5-(2,4-dimethoxy-phenyl)-3-methyl-cyclohex-2-enyl]-2-(2,4-dimethoxy-phenyl)-5,7-dimethoxy-3-(3-methyl-but-2-enyl)-chromen-4-one 

Downstream Products

• 36685-67-3 (E)-1-(2-hydroxy-4-methoxyphenyl)-3-(2,4-dimethoxyphenyl)prop-2-en-1-one 
• 688743-14-8 4,6-bis(2,4-dimethoxyphenyl)pyrimidin-2-amine 
• 22174-22-7 1,3-bis(2,4-dimethoxyphenyl)propan-1-one 
• 688743-13-7 C₃₂H₂₈N₂O₄ 
• 25972-30-9 (E)-1-(2,4-dihydroxyphenyl)-3-(2,4-dihydroxyphenyl)-2-propen-1-one 
• 116589-24-3 (2,4-Dimethoxy-phenyl)-[3-(2,4-dimethoxy-phenyl)-oxiranyl]-methanone 
• 79056-25-0 8-[(1R,5R,6S)-6-(2,4-Dimethoxy-benzoyl)-5-(2,4-dimethoxy-phenyl)-3-methyl-cyclohex-2-enyl]-2-(2,4-dimethoxy-phenyl)-5,7-dimethoxy-3-(3-methyl-but-2-enyl)-chromen-4-one 
• 75629-26-4 8-[(1S,5R,6S)-6-(2,4-Dimethoxy-benzoyl)-5-(2,4-dimethoxy-phenyl)-3-methyl-cyclohex-2-enyl]-2-(2,4-dimethoxy-phenyl)-5,7-dimethoxy-3-(3-methyl-but-2-enyl)-chromen-4-one 

Relevant articles and documents

Monodisperse NiPd alloy nanoparticles decorated on mesoporous graphitic carbon nitride as a catalyst for the highly efficient chemoselective reduction of α,β-unsaturated ketone compounds

Herein, the study reported extraordinary chemoselective reduction with selectivity (>99%) by the catalytic transfer hydrogenation of various α,β-unsaturated ketones with a catalyst of NiPd alloy nanoparticles decorated on mesoporous graphitic carbon nitride (NiPd/mpg-C3N4) under mild conditions in a water/methanol medium. NiPd alloy NPs were synthesized by the reduction of metal salts in oleylamine (OAm) solution with the help of borane-tert-butylamine and then decorated on mpg-C3N4via a liquid phase self-assembly method. The NiPd/mpg-C3N4 nanocatalyst was characterized by TEM, XRD and ICP-MS. The NiPd/mpg-C3N4 nanocatalyst is a highly active catalyst for the chemoselective reduction of α,β-unsaturated ketones and all organic compounds were converted with high yield and 99% selectivity. In addition, the catalyst can be reused five times without an important loss in reaction yield. This journal is

The synthesis of chalcones as anticancer prodrugs and their bioactivation in CYP1 expressing breast cancer cells

Background: Although the expression levels of many P450s differ between tumour and corresponding normal tissue, CYP1B1 is one of the few CYP subfamilies which is significantly and consistently overexpressed in tumours. CYP1B1 has been shown to be active within tumours and is capable of metabolising a structurally diverse range of anticancer drugs. Because of this, and its role in the activation of procarcinogens, CYP1B1 is seen as an important target for anticancer drug development. Objective: To synthesise a series of chalcone derivatives based on the chemopreventative agent DMU-135 and investigate their antiproliferative activities in human breast cancer cell lines which express CYP1B1 and CYP1A1. Method: A series of chalcones were synthesised in yields of 43-94% using the Claisen-Schmidt condensation reaction. These were screened using a MTT assay against a panel of breast cancer cell lines which have been characterised for CYP1 expression. Result: A number of derivatives showed promising antiproliferative activities in human breast cancer cell lines which express CYP1B1 and CYP1A1, while showing significantly lower toxicity towards a non-tumour breast cell line with no CYP expression. Experiments using the CYP1 inhibitors acacetin and α-naphthoflavone provided supporting evidence for the involvement of CYP1 enzymes in the bioactivation of these compounds. Conclusion: Chalcones show promise as anticancer agents with evidence suggesting that CYP1 activation of these compounds may be involved.

Bi(OTf)3 catalyzed disproportionation reaction of cinnamyl alcohols

Bi(OTf)3 catalyzed disproportionation reaction of cinnamyl alcohols provides chalcones and benzyl styrenes. The use of various metal triflates is investigated herein for facile and efficient redox transformation. A plausible mechanism has been proposed.