79017-08-6Relevant articles and documents
Active methylene compounds in a very effective approach to 3-substituted isobenzofuranones through tandem aldol/lactonization reactions
Di Mola, Antonia,Croce, Gianluca,More, Vijaykumar,De Caprariis, Paolo,Filosa, Rosanna,Massa, Antonio
experimental part, p. 6146 - 6151 (2012/09/07)
In this article we describe a new accessible methodology for the synthesis of isobenzofuran-1(3H)-ones. In this process we exploited an effective, economic, useful and environmentally benign K2CO3 catalyzed, solvent-free one-pot tandem aldol-lactonization reaction between active methylene compounds and methyl 2-carboxy benzaldehyde. A particularly simple work-up and purification procedure are additional advantages addressed to a general green chemistry approach to this important class of heterocyclic compounds.
