79135-52-7Relevant articles and documents
Rh(iii)-Catalyzed three-component cascade annulation to produce theN-oxopropyl chain of isoquinolone derivatives
He, Yuan,Liao, Xian-Zhang,Dong, Lin,Chen, Fen-Er
supporting information, p. 561 - 567 (2021/02/06)
Developing powerful methods to introduce versatile functional groups at theN-substituents of isoquinolone scaffolds is still a great challenge. Herein, we report a novel three-component cascade annulation reaction to efficiently construct theN-oxopropyl chain of isoquinolone derivativesviarhodium(iii)-catalyzed C-H activation/cyclization/nucleophilic attack, with oxazoles used both as the directing group and potential functionalized reagents.
Calcium carbide catalytically activated with tetra-: N -butyl ammonium fluoride for Sonogashira cross coupling reactions
Hosseini, Abolfazl,Pilevar, Afsaneh,Hogan, Eimear,Mogwitz, Boris,Schulze, Anne S.,Schreiner, Peter R.
, p. 6800 - 6807 (2017/08/22)
We report a novel method for the direct synthesis of mono- and bis-arylated alkynes utilizing catalytically activated CaC2 as the alkyne component. This fluoride-activated cross coupling reaction provides advantages over existing methods regarding operational simplicity, use of readily available starting materials, and low cost.
5,6,7-Trisubstituted 4-Aminopyrido[2,3-d]pyrimidines as Novel Inhibitors of Adenosine Kinase
Perner, Richard J.,Gu, Yu-Gui,Lee, Chih-Hung,Bayburt, Erol K.,McKie, Jeffery,Alexander, Karen M.,Kohlhaas, Kathy L.,Wismer, Carol T.,Mikusa, Joe,Jarvis, Michael F.,Kowaluk, Elizabeth A.,Bhagwat, Shripad S.
, p. 5249 - 5257 (2007/10/03)
The synthesis and structure-activity relationship of a series of 5,6,7-trisubstituted 4-aminopyrido[2,3-d]pyrimidines as novel nonnucleoside adenosine kinase inhibitors is described. A variety of alkyl, aryl, and heteroaryl substituents were found to be tolerated at the C5, C6, and C7 positions of the pyridopyrimidine core. These studies have led to the identification of analogues that are potent inhibitors of adenosine kinase with in vivo analgesic activity.