79154-57-7

Basic information

• Product Name: N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine
• Synonyms: N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine;Adenosine,N-benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]-;3',5'-TIPS-N-Bz-rA;3',5'-TIPS-N-Bz-Adenosine
• CAS NO: 79154-57-7
• Molecular Formula: C₂₉H₄₃N₅O₆Si₂
• Molecular Weight: 613.85262
• Mol File: 79154-57-7.mol
• Article Data: 19

Chemical Properties

• Appearance: /
• Density: 1.28±0.1 g/cm3(Predicted)
• PKA: 7.82±0.43(Predicted)
• CAS DataBase Reference: N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine(CAS DataBase Reference)
• NIST Chemistry Reference: N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine(79154-57-7)
• EPA Substance Registry System: N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine(79154-57-7)

Safety Data

• Hazardous Substances Data: 79154-57-7(Hazardous Substances Data)

Usage

Description

N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine is a chemical compound derived from adenosine, an essential component of DNA and RNA. This specific derivative features a benzoyl group and a tetrakis(1-methylethyl)-1,3-disiloxanediyl group attached to the 3' and 5' positions, which may contribute to its unique properties and potential applications in various fields.

Uses

Used in Synthesis of Branched Oligoribonucleotides:
N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine is used as a key component in the synthesis of branched oligoribonucleotides. These branched structures are designed to mimic intronic lariat RNA intermediates, which play a crucial role in the process of RNA splicing. N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine's unique structure allows for the creation of these complex RNA mimics, which can be used for studying the mechanisms of RNA splicing and developing potential therapeutic strategies targeting this process.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine may be utilized as a starting material or intermediate in the development of new drugs targeting RNA-related diseases. Its unique chemical structure could potentially be exploited to design novel therapeutic agents that modulate RNA splicing or interact with specific RNA targets, offering new treatment options for various conditions.
Used in Research and Development:
N-Benzoyl-3',5'-O-[1,1,3,3-tetrakis(1-methylethyl)-1,3-disiloxanediyl]adenosine can also be employed in research and development settings, particularly in the fields of molecular biology, biochemistry, and biotechnology. Researchers may use this compound to study the interactions between RNA and various proteins or small molecules, as well as to develop new tools and techniques for manipulating RNA structures and functions.

Upstream product

• 18043-71-5 1,1,3,3-tetraisopropyldisiloxane 
• 4546-55-8 N-benzoyladenosine 
• 69304-37-6 1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane 
• 98-88-4 benzoyl chloride 
• 58-61-7 adenosine 
• 10457-15-5 O^2'_,O3'_,O5'-tris-trimethylsilanyl-adenosine 
• 118684-36-9 O^2;_,O3'_,O5'-tris-trimethylsilyl-N⁶-benzoyladenosine 

Downstream Products

• 87865-81-4 N-{9-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(tetrahydro-furan-2-yloxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-benzamide 
• 90191-55-2 N⁶-Benzoyl-3',5'-O-TIPDSi-P-methyl-P-thioadenylyl-(2'-5')-N⁶,N⁶,O^2',O^3'-tetrabenzoyladenosine 
• 90108-20-6 N⁶-Benzoyl-3',5'-O-TIPDSi-P-methyl-P-thioadenylyl-(2'-5')-N⁶,N⁶,O^2',O^3'-tetrabenzoyladenosin 
• 90191-58-5 N⁶-Benzoyl-3',5'-O-TIPDSi(OH)-P-methyl-P-thioadenylyl-(2'-5')-N⁶,N⁶,O^2',O^3'-tetrabenzoyladenosine 
• 90108-23-9 C₉₈H₁₁₉N₁₅O₂₃P₂S₂Si₄ 
• 114494-74-5 6-N-benzoyl-3',5'-O-(tetraisopropyl-1,3-disiloxane-1,3-diyl)-3'-O-phosphiteamidite 
• 114515-40-1 Dimethyl-phosphoramidous acid (2R,3R,3aR,9aR)-2-(6-benzoylamino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester 9H-fluoren-9-ylmethyl ester 
• 114871-29-3 N-{9-[(2R,3R,3aR,9aR)-5,5,7,7-Tetraisopropyl-3-(1-methoxy-1-methyl-ethoxy)-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl]-9H-purin-6-yl}-benzamide 
• 136923-03-0 Trifluoro-methanesulfonic acid (2R,3R,3aR,9aR)-2-(6-benzoylamino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester 
• 103627-70-9 Phosphoric acid benzotriazol-1-yl ester (2R,3R,3aR,9aR)-2-(6-benzoylamino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl ester 2-chloro-phenyl ester 
• 142025-16-9 N⁶-benzoyl-3',5'-O-(1,1,3,3-tetraisopropyl-1,3-disiloxanediyl)adenosine-2'-(hydrogenphosphonate), triethylammonium salt 
• 148692-00-6 2'-O-(di-tert-butoxyphosphoryl)-3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-6-N-benzoyladenosine 
• 100802-96-8 Chloromethyl-phosphonic acid mono-[(2R,3R,3aR,9aR)-2-(6-benzoylamino-purin-9-yl)-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-3-yl] ester 
• 115264-87-4 C₅₄H₆₆N₇O₁₆PSi₂ 

Relevant articles and documents

SYNTHESIS OF 3'N NUCLEOSIDES THROUGH OXIME INTERMEDIATES AND RELATED COMPOUNDS

Provided herein are novel synthetic routes to amines through an oxime intermediate, e.g., 3'-N nucleosides and novel and intermediate compounds produced during these synthetic procedures.

BICYCLIC PEPTIDE LIGAND STING CONJUGATES AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

COMPOUNDS

Disclosed herein are 2'-spiro-nucleosides of formula I and derivatives thereof useful for treating a subject infected by hepatitis C virus or dengue virus. Formula (I), where z is a four-or five-membered ring selected from among radicals a-o represented b