79383-44-1

Basic information

• Product Name: METHYL 2-METHOXY-6-METHYLBENZOATE
• Synonyms: METHYL 2-METHOXY-6-METHYLBENZOATE;2-Methoxy-6-Methyl-benzoic acid Methyl ester;Benzoic acid, 2-Methoxy-6-Methyl-, Methyl ester
• CAS NO: 79383-44-1
• Molecular Formula: C₁₀H₁₂O₃
• Molecular Weight: 180.2
• EINECS: 1806241-263-5
• Mol File: 79383-44-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 95-96 °C(Press: 0.5 Torr)
• Appearance: /
• Density: 1.075±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: METHYL 2-METHOXY-6-METHYLBENZOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-METHOXY-6-METHYLBENZOATE(79383-44-1)
• EPA Substance Registry System: METHYL 2-METHOXY-6-METHYLBENZOATE(79383-44-1)

Safety Data

• Hazardous Substances Data: 79383-44-1(Hazardous Substances Data)

Usage

General Description

Methyl 2-methoxy-6-methylbenzoate is a chemical compound with the molecular formula C10H12O3. It is commonly used as a flavoring agent in the food and beverage industry due to its sweet, fruity aroma. It is also used in the manufacturing of fragrance and cosmetic products. This chemical is a clear, colorless liquid with a strong odor and is soluble in alcohol and ether. It is important to handle this chemical with care and follow safety guidelines as it can cause skin and eye irritation and should be stored in a cool, well-ventilated area away from direct sunlight and heat sources.

Upstream product

• 567-61-3 2-hydroxy-6-methylbenzoic acid 
• 77-78-1 dimethyl sulfate 
• 186581-53-3 diazomethane 
• 124-38-9 carbon dioxide 
• 100-84-5 1-methoxy-3-methyl-benzene 
• 67-56-1 methanol 
• 54884-55-8 2-methoxy-6-methyl-benzaldehyde 
• 50463-84-8 2-methoxy-6-methylbenzoyl chloride 
• 33528-09-5 methyl 6-methylsalicylate 
• 6161-65-5 2-methoxy-6-methyl-benzoic acid 
• 2944-49-2 2,3-dimethylanisole 
• 89244-40-6 2-(Bromomethyl)-3-methylanisole 
• 74-88-4 methyl iodide 
• 13506-76-8 2-methyl-6-nitrobenzoic acid 

Downstream Products

• 6161-65-5 2-methoxy-6-methyl-benzoic acid 
• 79383-45-2 2-(2-methoxy-6-methylphenyl)-2-propanol 
• 90798-59-7 methyl 6-dibromomethyl-2-methoxybenzoate 
• 943595-13-9 methyl 2-(bromomethoxy)-6-methoxybenzoate 
• 133379-09-6 methyl 5-bromo-2-methoxy-6-methylbenzoate 
• 133379-08-5 methyl 3-bromo-2-(bromomethyl)-6-methoxybenzoate 
• 13185-18-7 8-methoxy-1-tetralone 
• 186670-53-1 methyl 2-methoxy-6-(8-nonynyl)benzoate 
• 857652-04-1 2-(bromomethyl)-6-methoxybenzyl alcohol 
• 960506-52-9 C₁₄H₂₃SPO₅ 
• 960506-46-1 diethyl [(2-hydroxymethyl)-3-methoxybenzylsulfonyl]methylphosphonate 
• 960506-47-2 diethyl {[2-(tert-butyldimethylsilyloxy)methyl]-3-methoxybenzylsulfonyl}methylphosphonate 
• 480-47-7 hydrangenol 
• 82780-51-6 (+/-)-3-(4-methoxyphenyl)-8-methoxy-3,4-dihydroisocoumarin 

Relevant articles and documents

Preparation method of 2-methoxy-6-methylbenzoic acid

The invention discloses a synthesis process of 2-methoxy-6-methylbenzoic acid, which comprises the following steps: (1) reduction hydrogenation reaction: by taking 2-methyl-6-nitrobenzoic acid or methyl 2-methyl-6-nitrobenzoate as a raw material, methanol as a solvent, hydrogen as a hydrogen source and palladium on carbon or platinum on carbon as a catalyst, carrying out hydrogenation reduction to prepare 2-amino-6-methylbenzoic acid or methyl 2-amino-6-methylbenzoate; (2) diazotization, hydrolysis and esterification one-pot reaction: by taking the reduction product as a raw material, and methanol as a solvent, performing diazotization, hydrolysis and esterification reaction under the action of a diazotization reagent to prepare methyl 2-hydroxy-6-methylbenzoate; (3) methylation reaction: with methyl 2-hydroxy-6-methylbenzoate as a raw material and dimethyl sulfate as a methylation reagent, carrying out methylation reaction in the presence of alkali to prepare methyl 2-methoxy-6-methylbenzoate; and (4) hydrolysis reaction: mixing the methyl 2-methoxy-6-methylbenzoate with alkali and water, conducting heating for hydrolysis, conducting cooling after the reaction is completed, adjusting the pH value to 1-3 by using acid, separating out a product, and conducting filtering and drying to obtain the 2-methoxy-6-methylbenzoic acid.

Copper-Catalyzed One-Pot Synthesis of Dibenzofurans, Xanthenes, and Xanthones from Cyclic Diphenyl Iodoniums

Oxygenation of cyclic diphenyl iodoniums (CDPIs) with varied medium-ring sizes has been fully investigated. This practical copper-catalyzed tandem reaction of CDPIs with water as the oxygen source enables the construction of derivatised dibenzofurans and xanthenes at moderate to good yields. Moreover, structurally important xanthones are also successfully accessed under the oxygenation conditions with additional TEMPO.

Assessment of the regioselectivity in the condensation reaction of unsymmetrical o-phthaldialdehydes with alanine

One approach for the synthesis of isoindolinones, a privileged bioactive heterocyclic core structure, involves a condensation reaction of o-phthaldialdehydes with a suitable nitrogen-containing nucleophile. This fascinating reaction is revisited here in the context of the use of o-phthaldialdehydes that contain additional substituents in the aromatic ring leading to a detailed analysis of the regioselectivity of the reaction. Eleven monosubstituted o-phthaldialdehydes were synthesised and reacted with alanine. The regioselectivity observed across the eleven substrates led to the design of a disubstituted substrate that reacted with very high control. A gram-scale reaction followed by esterification gave one major regioisomer in high yield. In addition, the regioselectivity observed on reaction of two novel monodeuterated substrates led to an increased mechanistic understanding.