794464-41-8

Basic information

• Product Name: Piperidine, 3-[(4-fluorophenyl)methyl]-, (3R)-
• CAS NO: 794464-41-8
• Molecular Formula: C12H16FN
• Molecular Weight: 193.264
• Mol File: 794464-41-8.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Piperidine, 3-[(4-fluorophenyl)methyl]-, (3R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperidine, 3-[(4-fluorophenyl)methyl]-, (3R)-(794464-41-8)
• EPA Substance Registry System: Piperidine, 3-[(4-fluorophenyl)methyl]-, (3R)-(794464-41-8)

Safety Data

• Hazardous Substances Data: 794464-41-8(Hazardous Substances Data)

Upstream product

• 85908-96-9 2-oxopiperidine-1-carboxylic acid tert-butyl ester 
• 1604009-01-9 (R)-(+)-tert-butyl 3-(4-fluorobenzyl)-2-oxopiperidine-1-carboxylate 
• 1604008-31-2 (E)-tert-butyl 3-(4-fluorobenzylidene)-2-oxopiperidine-1-carboxylate 
• 611-71-2 (R)-Mandelic Acid 
• 382637-47-0 3-(4-fluorobenzyl)-piperidine 
• 94363-58-3 1-(2,2,2-Trifluoro-acetyl)-piperidin-2-one 
• 675-20-7 piperidin-2-one 
• 483305-46-0 (S)-3-(4-fluorobenzyl)-2-piperidone 
• 483305-37-9 (E)-3-(4-fluorobenzylidene)piperidin-2-one 
• 459-57-4 4-fluorobenzaldehyde 

Relevant articles and documents

Rhodium-catalyzed asymmetric hydrogenation of exocyclic α,β-unsaturated carbonyl compounds

A highly enantioselective hydrogenation of exocyclic α,β-unsaturated carbonyl compounds catalyzed by Rh/bisphosphine-thiourea (ZhaoPhos) has been developed, giving the corresponding α-chiral cyclic lactones, lactams and ketones with high yields and excellent enantioselectivities (up to 99% yield and 99% ee). Remarkably, the hydrogen bond between the substrate and the catalyst plays a critical role in this transformation. The synthetic utility of this protocol has been demonstrated by efficient synthesis of chiral 3-(4-fluorobenzyl)piperidine, a key chiral fragment of bioactive molecules.

Enantioselective hydrogenation of 3-alkylidenelactams: High-throughput screening provides a surprising solution

High-throughput screening of 256 potential catalysts (8 metal precursors × 32 phosphine ligands) has identified [(BDPP)Ir(COD)]BF4 as a catalyst for the enantioselective hydrogenation of 3-alkylidenelactams. This result is surprising given the