79654-37-8

Basic information

• Product Name: diphenyl(thiophen-2-yl)methanol
• CAS NO: 79654-37-8
• Molecular Formula: C₁₇H₁₄OS
• Molecular Weight: 266.3575
• Mol File: 79654-37-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 421.6°C at 760 mmHg
• Flash Point: 208.8°C
• Density: 1.212g/cm³
• Vapor Pressure: 7.31E-08mmHg at 25°C
• Refractive Index: 1.642
• CAS DataBase Reference: diphenyl(thiophen-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: diphenyl(thiophen-2-yl)methanol(79654-37-8)
• EPA Substance Registry System: diphenyl(thiophen-2-yl)methanol(79654-37-8)

Safety Data

• Hazardous Substances Data: 79654-37-8(Hazardous Substances Data)

Usage

Description

Diphenyl(thiophen-2-yl)methanol is a chemical compound with the molecular formula C19H16OS. It is a white to off-white crystalline solid that is insoluble in water but soluble in organic solvents.

Uses

Used in Pharmaceutical Industry:
Diphenyl(thiophen-2-yl)methanol is used as a building block in the synthesis of pharmaceuticals for its versatile chemical properties and potential biological activities.
Used in Agrochemical Industry:
Diphenyl(thiophen-2-yl)methanol is used as a building block in the synthesis of agrochemicals to develop new compounds for agricultural applications.
Used in Organic Synthesis:
Diphenyl(thiophen-2-yl)methanol is used as a chiral auxiliary in asymmetric synthesis to improve the selectivity and yield of enantioselective reactions.
Used in Catalysis:
Diphenyl(thiophen-2-yl)methanol is used as a ligand in catalysis to enhance the efficiency and selectivity of catalytic reactions.
Used in Environmental Research:
Diphenyl(thiophen-2-yl)methanol is being studied for its potential as an environmental contaminant to understand its effects on human health and the environment.
Used in Antimicrobial Applications:
Diphenyl(thiophen-2-yl)methanol has potential antimicrobial properties and is being investigated for its use in combating bacterial infections.
Used in Antifungal Applications:
Diphenyl(thiophen-2-yl)methanol has potential antifungal properties and is being studied for its use in treating fungal infections.
Used in Anti-inflammatory Applications:
Diphenyl(thiophen-2-yl)methanol has potential anti-inflammatory properties and is being researched for its use in reducing inflammation and related conditions.

Upstream product

• 119-61-9 benzophenone 
• 89180-57-4 2-thienylmagnesium iodide 
• 2786-07-4 2-thienyl lithium 
• 5713-61-1 thiophen-2-yl magnesium bromide 
• 135-00-2 2-Benzoylthiophene 
• 591-51-5 phenyllithium 
• 7664-93-9 sulfuric acid 
• 5449-99-0 diphenyl-2-thiophenyl acetic acid 
• 64-19-7 acetic acid 
• 16002-63-4 phenylmagnesium iodide 
• 76-84-6 triphenylmethyl alcohol 
• 4481-56-5 α,α-diphenyl-2-furanmethanol 
• 76-93-7 Benzilic acid 
• 3437-95-4 2-Iodothiophene 

Downstream Products

• 1726-12-1 1,1-diphenylpentane 
• 1530-11-6 1,1-diphenyl-pent-1-ene 
• 51526-01-3 1,1,10,10-Tetraphenyl-decan 
• 61532-53-4 (2-thienyl)diphenylmethane 
• 109298-90-0 Diphenyl(2-thienyl)methyl cation 
• 825-55-8 2-phenylthiophene 
• 119-61-9 benzophenone 
• 42545-43-7 2-(4-methoxyphenyl)thiophene 
• 59156-12-6 2-(3-trifluoromethylphenyl)thiophene 
• 5432-54-2 (2-methylphenyl)diphenylmethanol 
• 4481-56-5 α,α-diphenyl-2-furanmethanol 
• 847-83-6 p-methoxytrityl alcohol 
• 64655-62-5 (2-methoxyphenyl)(diphenyl)methanol 
• 21856-96-2 Diphenyl<4-(trifluormethyl)phenyl>methanol 

Relevant articles and documents

Iron-catalysed 1,2-aryl migration of tertiary azides

1,2-Aryl migration of α,α-diaryl tertiary azides was achieved by using the catalytic system of FeCl2/N-heterocyclic carbene (NHC) SIPr·HCl. The reaction generated aniline products in good yields after one-pot reduction of the migration-resultant imines.

Palladium-catalyzed arylation of α,α-disubstituted arylmethanols via cleavage of a C-C or a C-H bond to give biaryls

The palladium-catalyzed arylation of α,α-disubstituted arylmethanols with aryl halides proceeds not only via C-H bond cleavage at the ortho-position, but also via cleavage of the sp2-sp3 C-C bond with the liberation of ketones (β-carbon elimination) to give the corresponding biaryls. Both reactions appear to occur through common arylpalladium(II) alcoholate intermediates. The results of systematic studies with respect to which C-C or C-H bond is preferentially cleaved in the arylation are reported. Among the important findings is the selective elimination of ortho-substituted aryl groups even from aryl(diphenyl)methanols due to steric reasons. Thus, various biaryls having ortho-substituents can be produced efficiently by treatment of the corresponding aryl(diphenyl or dimethyl)methanols with aryl bromides and chlorides.

Photochemical reactions of Thienyl-, Bithienyl-, Terthienyl- and Thienylaroyl-methanols

Photochemical reactions of some thienyl-, bithienyl-, terthienyl- and thienylaroyl-methanols were studied in the neat state as well as in solvents like methanol and benzene.The terthienylmethanols were found to be susceptible to photo-sensitized oxidation which was inhibited by singlet oxygen quenchers.The photoproducts were isolated, characterised by spectroscopic methods and in some cases by synthesis.