79925-03-4

Basic information

• Product Name: 4-(3-NITROPHENYL)-3-THIOSEMICARBAZIDE
• Synonyms: 4-(3-NITROPHENYL)-3-THIOSEMICARBAZIDE
• CAS NO: 79925-03-4
• Molecular Formula: C₇H₈N₄O₂S
• Molecular Weight: 212.23
• Mol File: 79925-03-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 161-163°C (dec.)
• Boiling Point: 358.8 °C at 760 mmHg
• Flash Point: 170.8 °C
• Appearance: /
• Density: 1.535 g/cm³
• Vapor Pressure: 2.49E-05mmHg at 25°C
• Refractive Index: 1.759
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-(3-NITROPHENYL)-3-THIOSEMICARBAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3-NITROPHENYL)-3-THIOSEMICARBAZIDE(79925-03-4)
• EPA Substance Registry System: 4-(3-NITROPHENYL)-3-THIOSEMICARBAZIDE(79925-03-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 79925-03-4(Hazardous Substances Data)

Usage

General Description

4-(3-Nitrophenyl)-3-thiosemicarbazide is a potentially hazardous chemical compound with the molecular formula C7H7N5O2S. It is a white to yellow crystalline solid that is used in various organic synthesis processes. 4-(3-NITROPHENYL)-3-THIOSEMICARBAZIDE is known for its nitro and thiosemicarbazide functional groups, which make it highly reactive and useful in the formation of other chemical compounds. 4-(3-Nitrophenyl)-3-thiosemicarbazide is also known to have potential toxic, irritant, and environmental hazards, requiring proper handling and disposal procedures to minimize risk. Due to its versatile reactivity, this compound finds applications in the pharmaceutical and agricultural industries as a precursor for the synthesis of various biologically active compounds.

InChI:InChI=1/C7H8N4O2S/c8-10-7(14)9-5-2-1-3-6(4-5)11(12)13/h1-4H,8H2,(H2,9,10,14)

Upstream product

• 3529-82-6 3-nitrophenyl isothiocyanate 
• 75-15-0 carbon disulfide 
• 99-09-2 3-nitro-aniline 

Downstream Products

• 79924-98-4 (Z)-camphorquinone 4-m-nitrothiosemicarbazone 
• 79924-98-4 (E)-camphorquinone 4-m-nitrothiosemicarbazone 
• 80650-20-0 (3-Nitro-phenyl)-[1,2,3,4]thiatriazol-5-yl-amine 
• 7025-16-3 m-NPTSH 
• 1224696-46-1 C₁₅H₁₄N₄O₃S 
• 1398501-20-6 2-(5-chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)-N-(3-nitrophenyl)-1-hydrazinecarbothioamide 

Relevant articles and documents

Co(II), Ni(II) and Cu(II) complexes with coumarin-8-yl Schiff-bases: Spectroscopic, in vitro antimicrobial, DNA cleavage and fluorescence studies

A new series of Co(II), Ni(II) and Cu(II) complexes of the type ML·2H2O of Schiff-bases derived from m-substituted thiosemicarbazides and 8-acetyl-7-hydroxy-4-methylcoumarin have been synthesized and characterized by spectroscopic studies. Schiff-bases exhibit thiol-thione tautomerism wherein sulphur plays an important role in the coordination. The coordination possibility of the Schiff-bases towards metal ions have been proposed in the light of elemental analyses, spectral (IR, UV-vis, FAB-mass, ESR and fluorescence), magnetic and thermal studies. The low molar conductance values in DMF indicate that, the metal complexes are non-electrolytes. The cyclic voltammetric studies suggested that, the Cu(II) and Ni(II) complexes are of single electron transfer quasi-reversible nature. The Schiff-bases and its metal complexes have been evaluated for their in vitro antibacterial (Escherichia coli, Staphilococcus aureus, Bascillus subtilis and Salmonella typhi) and antifungal activities (Candida albicans, Cladosporium and Aspergillus niger) by MIC method. The Schiff-base I and its metal complexes exhibited DNA cleavage activity on isolated DNA of A. niger.

Synthesis and antibacterial activity of thiosemicarbazones

The synthesis of 1-[(2′-hydroxy-4′-isopropoxy-5′- nitrophenyl)-ethanone]-4-(aryl)-3-thiosemicarbazones are carried out by refluxing 4-aryl-3-thiosemicarbazides and 2-hydroxy-4-isopropoxy-5- nitroacetophenone in stoichiometric amounts dissolved in aqueous

Preparation of some 1,2,3,4-tetrazoles

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