79951-46-5

Basic information

• Product Name: (1R,4S)-Sertraline HCl
• Synonyms: (1R,4S)-Sertraline HCl
• CAS NO: 79951-46-5
• Molecular Weight: 306.235
• Mol File: 79951-46-5.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: (1R,4S)-Sertraline HCl(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,4S)-Sertraline HCl(79951-46-5)
• EPA Substance Registry System: (1R,4S)-Sertraline HCl(79951-46-5)

Safety Data

• Hazardous Substances Data: 79951-46-5(Hazardous Substances Data)

Usage

Description

(1R,4S)-Sertraline HCl is a specific enantiomer of sertraline hydrochloride, a selective serotonin reuptake inhibitor (SSRI) used for the treatment of various mental health conditions. It functions by increasing serotonin levels in the brain, which can improve mood, sleep, appetite, and energy levels. The (1R,4S) enantiomer is the active form of the drug, responsible for its therapeutic effects.
Used in Pharmaceutical Industry:
(1R,4S)-Sertraline HCl is used as an antidepressant medication for the treatment of depression, anxiety, panic disorder, obsessive-compulsive disorder, and other mental health conditions. It is prescribed in tablet or oral solution form and is generally well-tolerated by most patients, with common side effects including nausea, headache, and insomnia.

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Relevant articles and documents

Deactivation mechanisms of iodo-iridium catalysts in chiral amine racemization

The homogenous, [IrCp?I2]2, SCRAM catalyst (1) is active in the racemization of chiral amines. NMR, kinetic and structural mechanistic studies have determined the cause of catalyst deactivation to occur when ammonia or methylamine are liberated by hydrolysis or aminolysis of the intermediate imine, which tightly coordinate to the iridium centre to block turnover. Control of moisture and substrate concentration can suppress deactivation, whilst partial reactivation of spent catalyst was identified using hydroiodic acid.

Spiro[4,4]-1,6-nonadiene-based phosphine-oxazoline ligands for iridium-catalyzed enantioselective hydrogenation of ketimines

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A low-waste process to sertraline by diastereomeric crystal resolution and waste isomer racemisation

A semi-continuous method for recovering waste sertraline isomers from a diastereomeric crystallisation process is described in which the mother liquors from a highly selective mandelic acid resolution for the (1S,4S) isomer are treated sequentially with S