79560-18-2

Basic information

• Product Name: 4-(3,4-DICHLOROPHENYL)-4-PHENYLBUTYRIC ACID
• Synonyms: 4-(3,4-DICHLOROPHENYL)-4-PHENYLBUTYRIC ACID
• CAS NO: 79560-18-2
• Molecular Formula: C₁₆H₁₄Cl₂O₂
• Molecular Weight: 309.18716
• Mol File: 79560-18-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 118-120 °C(Solv: hexane (110-54-3))
• Boiling Point: 432.2±40.0 °C(Predicted)
• Appearance: /
• Density: 1.301±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.61±0.10(Predicted)
• CAS DataBase Reference: 4-(3,4-DICHLOROPHENYL)-4-PHENYLBUTYRIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(3,4-DICHLOROPHENYL)-4-PHENYLBUTYRIC ACID(79560-18-2)
• EPA Substance Registry System: 4-(3,4-DICHLOROPHENYL)-4-PHENYLBUTYRIC ACID(79560-18-2)

Safety Data

• Hazardous Substances Data: 79560-18-2(Hazardous Substances Data)

Usage

Description

4-(3,4-DICHLOROPHENYL)-4-PHENYLBUTYRIC ACID is an organic compound that serves as a crucial reactant in the synthesis of various pharmaceutical compounds. It is characterized by its chemical structure, which includes a butyric acid backbone with a 3,4-dichlorophenyl and a phenyl group attached to it.

Uses

Used in Pharmaceutical Industry:
4-(3,4-DICHLOROPHENYL)-4-PHENYLBUTYRIC ACID is used as a reactant for the synthesis of (+)(-)-Sertraline (S280000), a selective serotonin reuptake inhibitor (SSRI). It plays a significant role in the development of antidepressant medications, which are essential for treating various mental health disorders, including depression and anxiety.
As an intermediate in the production of Sertraline, 4-(3,4-DICHLOROPHENYL)-4-PHENYLBUTYRIC ACID contributes to the overall effectiveness of the drug in modulating serotonin levels in the brain, thereby providing relief from depressive symptoms and improving the quality of life for patients suffering from these conditions.

Upstream product

• 79560-17-1 4-(3,4-dichlorophenyl)-4-phenylbut-3-enoic acid 
• 95609-48-6 rac-5-(3,4-dichlorophenyl)dihydrofuran-2(3H)-one 
• 71-43-2 benzene 
• 147189-93-3 (R)-(+)-5-(3,4-dichlorophenyl)dihydrofuran-2(3H)-one 
• 50597-19-8 3-(3,4-dichlorobenzoyl)-propionic acid 
• 6284-79-3 3,4-dichlorobenzophenone 
• 79560-16-0 3-(ethoxycarbonyl)-4-(3,4-dichlorophenyl)-4-phenylbut-3-enoic acid 
• 118528-87-3 4-(3,4-dichlorophenyl)-4-hydroxybutanoic acid 
• 95-50-1 1,2-dichloro-benzene 
• 1198097-90-3 methyl 4-(3,4-dichlorophenyl)-4-phenylbutanoate 
• 2522-81-8 2-<(2,2-dimethylpropanoyl)oxy>-1-phenylethanone 
• 108-86-1 bromobenzene 

Downstream Products

• 149620-65-5 4-(3,4-dichlorophenyl)-4-phenylbutyric acid 
• 79617-95-1 cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine 
• 848130-45-0 [4-(3,4-dichlorophenyl)-4-phenylbutyryl]carbamic acid methyl ester 
• 374778-33-3 [4-(3,4-dichlorophenyl)-4-phenyl-butyryl]-carbamic acid methyl ester 
• 79560-19-3 4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one 
• 79560-20-6 N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine 
• 79617-98-4 (1R,4R)-sertraline 
• 91797-60-3 trans-(1S,4R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine 
• 79951-46-5 trans-(1R,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine 
• 79617-96-2 Sertraline 
• 79836-45-6 trans-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine 

Relevant articles and documents

α,α-Diarylethylene Glycols as Valuable Precursor for Synthesis of 1,1-Diarylethenes and α,α-Diaryl Acetaldehydes

Towards assembling of diarylmethine unit present in biologically important molecules, we have developed a new Weinreb Amide (WA) based building block derived from glycolic acid. The WA functionality present in this building block permits the sequential addition of various arylmagnesium bromide reagents in a controlled manner that enables assembly of a diarylmethine unit. The developed synthetic route provides easy access to important diarylethenes and α,α-diarylethylene glycols. The synthesized α,α-diarylethylene glycols provide access to synthetically important symmetrical and unsymmetrical α,α-diaryl acetaldehydes as valuable intermediates.

IMPROVED MANUFACTURING PROCEDURE FOR THE PREPARATION OF POLYMORPHIC FORM II OF CIS-(1S)-N-METHYL-4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHLENEAMINE HYDROCHLORIDE (SERTRALINE HYDROCHLORIDE)

The present invention relates to the improved, scalable and efficient manufacturing procedure for the preparation of the antidepressant Cis-(1S)-N-Methyl-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-1-napthaleneamine hydro chloride, Sertraline Hydrochloride polymorphic form II. The present invention further relates to the improved and modified procedures for preparing, separating and isolating the key intermediates involved in the preparationof Sertraline Hydrochloride polymorphic form II. The present invention also further relates to the use of novel reagents or a combination thereof and new methodologies to prepare some o'f the key intermediates involved in the preparation of Polymorphic Form II of Sertraline Hydrochloride.

Process for preparing a 4,4-diphenylbutanoic acid derivative

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