79836-45-6

Basic information

• Product Name: rac trans Sertraline
• Synonyms: (1R,4S)-rel-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine;rac trans Sertraline;trans-4-(3,4-Dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthalenamine;(1R,4S)-rel-;(1R, 4S)-trans-Sertraline HCl
• CAS NO: 79836-45-6
• Molecular Formula: C₁₇H₁₇Cl₂N
• Molecular Weight: 306.23
• Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 79836-45-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 416.33°C at 760 mmHg
• Flash Point: 205.589°C
• Appearance: /
• Density: 1.255g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.621
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Dichloromethane (Sparingly), Methanol (Slightly)
• PKA: 9.47±0.40(Predicted)
• CAS DataBase Reference: rac trans Sertraline(CAS DataBase Reference)
• NIST Chemistry Reference: rac trans Sertraline(79836-45-6)
• EPA Substance Registry System: rac trans Sertraline(79836-45-6)

Safety Data

• Hazardous Substances Data: 79836-45-6(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Oil

Uses

Different sources of media describe the Uses of 79836-45-6 differently. You can refer to the following data:
1. Rac-trans-Sertraline is used for the treatment of menopause and mood, anxiety, and cognitive disorders. They block uptake of dopamine and norepinephrine.
2. rac-trans-Sertraline (Sertraline EP Impurity A) is used for the treatment of menopause and mood, anxiety, and cognitive disorders. They block uptake of dopamine and norepinephrine.

InChI:InChI=1/C17H17Cl2N/c1-20-17-9-7-12(13-4-2-3-5-14(13)17)11-6-8-15(18)16(19)10-11/h2-6,8,10,12,17,20H,7,9H2,1H3/t12-,17+/m0/s1

Upstream product

• 79560-20-6 N-[4-(3,4-dichlorophenyl)-3,4-dihydro-1(2H)-naphthalenylidene]methanamine 
• 6284-79-3 3,4-dichlorobenzophenone 
• 79560-19-3 4-(3,4-dichlorophenyl)-3,4-dihydro-2H-naphthalen-1-one 
• 79560-18-2 4-(3,4-dichlorophenyl)-4-phenylbutanoic acid 
• 79560-17-1 4-(3,4-dichlorophenyl)-4-phenylbut-3-enoic acid 
• 149620-65-5 4-(3,4-dichlorophenyl)-4-phenylbutyric acid 
• 79560-16-0 3-(ethoxycarbonyl)-4-(3,4-dichlorophenyl)-4-phenylbut-3-enoic acid 
• 95-50-1 1,2-dichloro-benzene 
• 90-15-3 α-naphthol 

Downstream Products

• 91797-60-3 trans-(1S,4R)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine 
• 79951-46-5 trans-(1R,4S)-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine 
• 79617-89-3 cis-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-naphthaleneamine hydrochloride 
• 674768-38-8 (1S,4R)-sertraline-(S)-mandelate 
• 79617-99-5 trans-N-methyl-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-naphthalenamine hydrochloride 

Relevant articles and documents

COMBINATIONS OF ESZOPICLONE AND TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-N-METHYL-1-NAPTHALENAMINE OR TRANS 4-(3,4-DICHLOROPHENYL)-1,2,3,4-TETRAHYDRO-1-NAPTHALENAMINE, AND METHODS OF TREATMENT OF MENOPAUSE AND MOOD, ANXIETY, AND COGNITIVE DISORDERS

One aspect of the present invention relates to pharmaceutical compositions containing two or more active agents that when taken together can be used to treat, e.g., menopause, mood disorders, anxiety disorders, or cognitive disorders. The first component of the pharmaceutical composition is a sedative eszopiclone. The second component of the pharmaceutical composition is trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-napthalenamine or trans 4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-1-napthalenamine. The present invention also relates to a method of treating menopause, perimenopause, mood disorders, anxiety disorders, and cognitive disorders.

IMPROVED SYNTHESIS OF RACEMIC SERTRALINE

The present invention relates to the use or natural vegetable flavouring components as flavouring agents in chewing gum coating. The addition of a natural vegetable component to a chewing gum coating results in increased flavour sensation. The invention also relates to a method for the preparation of a chewing gum wherein the coating comprises a natural vegetable component as flavouring agent. The chewing gum comprises a) an insoluble gum base; b) a water soluble portion; c) a coating comprising a flavouring agent wherein at least 10% by weight of the flavouring agent is a natural vegetable flavouring agent comprising plant cellular material.