79952-42-4 Usage
Description
6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one is a complex polyketide compound characterized by its unique molecular structure and stereochemistry. It features a hydroxy substituent at position 8, which is a key functional group that may contribute to its potential biological activities and applications.
Uses
Used in Pharmaceutical Industry:
6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one is used as an intermediate in the synthesis of hypolipidemic drugs, such as Simvastatin and Lovastatin analogs. These drugs are known for their cholesterol-lowering properties, making them valuable in the treatment and management of hyperlipidemia and related cardiovascular conditions.
Used in Drug Development:
Due to its unique chemical properties and potential biological activities, 6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one may also be explored for its potential use in drug development. Its hydroxy substituent at position 8 could be exploited for the design of new pharmaceutical agents targeting various therapeutic areas, such as cardiovascular, metabolic, or neurological disorders.
Used in Chemical Research:
As a complex polyketide, 6(R)-[2-(8(S)-Hydroxy]-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl]ethyl-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-one may also serve as a valuable compound for chemical research. Its unique structure and properties can be studied to gain insights into the synthesis, reactivity, and potential applications of similar polyketide compounds in various fields, including pharmaceuticals, materials science, and agrochemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 79952-42-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 7,9,9,5 and 2 respectively; the second part has 2 digits, 4 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 79952-42:
(7*7)+(6*9)+(5*9)+(4*5)+(3*2)+(2*4)+(1*2)=184
184 % 10 = 4
So 79952-42-4 is a valid CAS Registry Number.
InChI:InChI=1/C19H28O4/c1-11-7-13-4-3-12(2)16(19(13)17(21)8-11)6-5-15-9-14(20)10-18(22)23-15/h3-4,7,11-12,14-17,19-21H,5-6,8-10H2,1-2H3/t11?,12-,14+,15+,16-,17?,19-/m0/s1
79952-42-4Relevant articles and documents
HMG-COA REDUCTASE DEGRADATION INDUCING COMPOUND
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Paragraph 463-466, (2021/10/11)
The present invention relates HMG-CoA reductase degradation inducing compounds. Specifically, the present invention relates a bifunctional compound in which a HMG-CoA reductase binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention also relates a method for preparing the compounds, and a method for degradation of HMG-CoA reducatase using the compounds, as well as use for prevention or treatment of HMG-CoA reductase related diseases using the compounds.
Hydroxy methyl glutaryl coenzyme A reductase inhibitors
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Paragraph 0074; 0075; 0076, (2017/04/29)
The invention relates to a compound, in particular to an HMG-GoA reductase inhibitor. The HMG-GoA reductase inhibitor is ester formed by naphthol and Cn polyhydroxyalkanoate or Cn olefine acid of the compound in the formula I, wherein n is an integer from six to fourteen. The compound can be effectively used for treating or preventing dyslipidemia, for example, the compound can effectively treat or prevent hypercholesteremia or mixed type hyperlipidemia.
DUAL ACTION INHIBITORS AGAINST HISTONE DEACETYLASES AND 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE
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Paragraph 0099; 0100; 0101, (2014/08/06)
Disclosed herein are novel compounds of formula (I), and uses thereof. The compounds of Formula (I) are inhibitors of histone deacetylases (HDACs) and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (HMGR). Also provided are methods of using the
