80548-31-8

Basic information

• Product Name: (R)-(+)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE
• Synonyms: (R)-2-(1-PHENYLETHYLAMINO)ETHANOL;(R)-(+)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE;(R)-(+)-N-(2-HYDROXYETHYL)-PHENYLETHYLAMINE;TIMTEC-BB SBB010055;(R)-(+)-N-(2-Hydroxyethyl)-alpha-methylbenzylamine;(+)-N-(2-Hydroxyethyl)-Alpha-Phenylethylamine, 99%;(R)-(+)-N-(2-Hydroxyethyl)-alpha-phenylethylamine,99%;(R)-(+)-N-(2-Hydroxyethyl)-alpha-phenylethylamine(R)-(+)-N-(2-Hydroxyethyl)-alpha-methylbenzylamine(R)-(+)-2-[(1-Phenylethyl)-amino]-ethanol
• CAS NO: 80548-31-8
• Molecular Formula: C₁₀H₁₅NO
• Molecular Weight: 165.23
• Mol File: 80548-31-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 293.09°C (rough estimate)
• Flash Point: 114.4°C
• Appearance: Clear colorless/Liquid
• Density: 1.0203 (rough estimate)
• Vapor Pressure: 0.00129mmHg at 25°C
• Refractive Index: 1.532-1.535
• Storage Temp.: 2-8°C
• PKA: 14.74±0.10(Predicted)
• CAS DataBase Reference: (R)-(+)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE(80548-31-8)
• EPA Substance Registry System: (R)-(+)-N-(2-HYDROXYETHYL)-ALPHA-PHENYLETHYLAMINE(80548-31-8)

Safety Data

• Hazard Codes: Xi,T
• Statements: 36/37/38-36-25
• Safety Statements: 37/39-26-45
• Hazardous Substances Data: 80548-31-8(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless liquid

InChI:InChI=1/C10H15NO/c1-9(11-7-8-12)10-5-3-2-4-6-10/h2-6,9,11-12H,7-8H2,1H3/t9-/m1/s1

Upstream product

• 164219-31-2 ethyl (S)-2-oxo-2-((1-phenylethyl)amino)acetate 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 107-07-3 2-chloro-ethanol 
• 164219-32-3 (S)-2-oxo-2-((1-phenylethyl)amino)acetic acid 
• 540-51-2 2-bromoethanol 
• 75-21-8 oxirane 
• 2627-86-3 (-)-α-methylbenzylamine 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 185527-09-7 (R)-N-(1-phenylethyl)oxalamic acid 

Downstream Products

• 88154-70-5 2-(1,2-dipalmitoyl-sn-glycero)-3-(1-methylbenzyl)-2-<17O>oxo-1,3,2-oxazaphospholidine 
• 88035-48-7 2-(1,2-dipalmitoyl-sn-glycero)-3-(1-methylbenzyl)-2-<17O>oxo-1,3,2-oxazaphospholidine 
• 100596-36-9 hydrobromide (-)-N-(2-bromzethyl)-α-phenylethylamine 
• 80548-32-9 Hexadecanoic acid (S)-1-hexadecanoyloxymethyl-2-[2-oxo-3-((R)-1-phenyl-ethyl)-2λ⁵-[1,3,2]oxazaphospholidin-2-yloxy]-ethyl ester 
• 207690-58-2 ((S)-1-Phenyl-ethyl)-(2-triisopropylsilanyloxy-ethyl)-amine 
• 817168-33-5 4-((S)-1-Phenyl-ethyl)-morpholine-2,3-dione 
• 869800-22-6 (S)-2-[(2-hydroxy-ethyl)-(1-phenyl-ethyl)-amino]-acetonitrile 
• 869800-28-2 benzyl (S)-[(2-hydroxy-ethyl)-(1-phenyl-ethyl)-amino]ethanoate 
• 869800-24-8 [1(1S),2S]-1-(1-phenyl-ethyl)-azetidine-2-carbonitrile 
• 869800-25-9 [1(1S),2R]-1-(1-phenyl-ethyl)-azetidine-2-carbonitrile 
• 869800-23-7 (S)-2-[(2-chloro-ethyl)-(1-phenyl-ethyl)-amino]-acetonitrile 
• 249734-37-0 benzyl [1(1S,2R)]-1-(1-phenyl-ethyl)-azetidine-2-carboxylate 
• 247051-66-7 benzyl [1(1S,2S)]-1-(1-phenyl-ethyl)-azetidine-2-carboxylate 
• 869800-29-3 benzyl (S)-[(2-chloro-ethyl)-(1-phenyl-ethyl)-amino]ethanoate 

Relevant articles and documents

Preparation methods of aprepitant impurity

The invention discloses preparation methods of an aprepitant impurity, which comprise isomer impurity synthesis method of six aprepitant key intermediates (2R, 3S)-2-[(1R)-1-[3, 5-bis (trifluoromethyl)-phenyl] ethoxy]-3-(4-fluorophenyl) morpholine, respectively, synthesis of four diastereomer impurities, synthesis of one enantiomer impurity and synthesis of one by-product impurity. The methods have the beneficial effects that the five synthesis methods are simple and feasible, the raw materials are easy to obtain, the conditions are mild, the cost is low, the production is facilitated, and meanwhile, the isomer impurities of the synthesized aprepitant key intermediate provide a new intermediate raw material for the preparation of aprepitant.

Chemodivergent synthesis of 7-aryl/alkyl-6-hydroxy-1,4-oxazepan-5-ones and 2-[aryl/alkyl(hydroxy)methyl]morpholin-3-ones from a common epoxyamide precursor

We present here a regiospecific synthesis of 7-alkyl- or 7-aryl-6-hydroxy-1,4-oxazepan-5-ones and 2-[aryl(hydroxy)methyl]- or 2-(1-hydroxyalkyl)morpholin-3-ones from a diastereomeric mixture of trans-3-alkyl- or -3-aryl-N-(2-hydroxyethyl)-N-(1-phenylethyl)oxirane-2- carboxamides. This chemodivergent synthesis is easily controlled by an appropriate choice of cyclization reaction conditions. Georg Thieme Verlag Stuttgart - New York.

Syntheses of morpholine-2,3-diones and 2-hydroxymorpholin-3-ones: Intermediates in the synthesis of aprepitant

The preparation of morpholine-2,3-diones and 2-hydroxymorpholin-3-ones from N-substituted β-amino alcohols is reported. These were useful intermediates in the synthesis and development of aprepitant.