805994-92-7Relevant articles and documents
Uncovering an allosteric mode of action for a selective inhibitor of human bloom syndrome protein
Chen, Xiangrong,Ali, Yusuf I.,Fisher, Charlotte EL,Arribas-Bosacoma, Raquel,Rajasekaran, Mohan B.,Williams, Gareth,Walker, Sarah,Booth, Jessica R.,Hudson, Jessica JR,Mark Roe,Pearl, Laurence H.,Ward, Simon E.,Pearl, Frances MG,Oliver, Antony W.
, (2021/04/02)
BLM (Bloom syndrome protein) is a RECQ-family helicase involved in the dissolution of complex DNA structures and repair intermediates. Synthetic lethality analysis implicates BLM as a promising target in a range of cancers with defects in the DNA damage r
PIPERAZINE AND PIPERIDINE BIARYL DERIVATIVES
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Page/Page column 76, (2010/11/28)
This invention relates to piperazine and piperidine biaryl compounds of Formula (I) or a pharmaceutically acceptable prodrug, salt, polymorph, solvate, enantiomer, diastereomer, racemate, mixture of stereoisomers thereof, or derivative thereof; and to processes for preparing the compounds or pharmaceutical compositions containing the same. The compounds and pharmaceutical compositions of the present invention are provided for use in the treatment of HIV infection and/or AIDS.