80745-09-1 Usage
General Description
Z-ARG(MTR)-OH CHA is a chemical compound consisting of N-(Z-arginine)-N-(m-trifluoromethyl-dinitrobenzoyl)-O-methyl ester, commonly known as Z-ARG(MTR)-OH CHA. Z-ARG(MTR)-OH CHA is typically used in chemical synthesis as a protecting group for the amino acid arginine. The Z- and MTR- groups serve to protect the guanidine and carboxyl groups of arginine, respectively, during chemical reactions. The CHA moiety refers to the use of this compound in the synthesis of cyclic hexapeptides. Overall, Z-ARG(MTR)-OH CHA plays a critical role in facilitating the synthesis of complex peptides and proteins in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 80745-09-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,7,4 and 5 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 80745-09:
(7*8)+(6*0)+(5*7)+(4*4)+(3*5)+(2*0)+(1*9)=131
131 % 10 = 1
So 80745-09-1 is a valid CAS Registry Number.
InChI:InChI=1/C24H32N4O7S.C6H13N/c1-15-13-20(34-4)16(2)17(3)21(15)36(32,33)28-23(25)26-12-8-11-19(22(29)30)27-24(31)35-14-18-9-6-5-7-10-18;7-6-4-2-1-3-5-6/h5-7,9-10,13,19H,8,11-12,14H2,1-4H3,(H,27,31)(H,29,30)(H3,25,26,28);6H,1-5,7H2/t19-;/m0./s1
80745-09-1Relevant articles and documents
Further Studies on the Use of Multi-substituted Benzenesulfonyl Groups for Protection of the Guanidino Function of Arginine
Fujino, Masahiko,Wakimasu, Mitsuhiro,Kitada, Chieko
, p. 2825 - 2831 (2007/10/02)
Various multi-substituted benzenesulfonyl protecting groups for the guanidino function of arginine, removable under mild conditions such as with trifluoroacetic acid (TFA)-thioanisole, were studied.Among them, the 4-methoxy-2,6-dimethylbenzenesulfonyl (Mds) group, the 2,3,4,5,6-pentamethylbenzenesulfonyl (Pme) group, and the 4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) group were found to be useful.Both Mds and Pme show considerable resistance to TFA and, therefore, are suitable for procedures in which the intermediates are deprotected by TFA treatment, while Mtr is the most useful protecting group when TFA treatment is not necessary.Keywords---4-methoxy-2,6-dimethylbenzenesulfonyl (Mds); 2,4,6-trimethoxybenzenesulfonyl (Mtb); 2,3,4,5,6-pentamethylbenzenesulfonyl (Pme); 4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr); trifluoroacetic acid-thioanisole deprotection