80745-10-4Relevant articles and documents
SOLUTION SYNTHESIS OF THE HEPTADECAPEPTIDE SEQUENCE OF VESPULAKININ 1
Biondi, Laura,Cavaggion, Franco,Filira, Fernando,Rocchi, Raniero
, p. 427 - 434 (2007/10/02)
Solution synthesis is described of the carbohydrate-free heptadecapeptide sequence of vespulakinin 1.The segment condensation strategy has been utilized to assemble the complete sequence.Carboxyl activation has been achieved by the 1-succinimidyl esters m
Further Studies on the Use of Multi-substituted Benzenesulfonyl Groups for Protection of the Guanidino Function of Arginine
Fujino, Masahiko,Wakimasu, Mitsuhiro,Kitada, Chieko
, p. 2825 - 2831 (2007/10/02)
Various multi-substituted benzenesulfonyl protecting groups for the guanidino function of arginine, removable under mild conditions such as with trifluoroacetic acid (TFA)-thioanisole, were studied.Among them, the 4-methoxy-2,6-dimethylbenzenesulfonyl (Mds) group, the 2,3,4,5,6-pentamethylbenzenesulfonyl (Pme) group, and the 4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr) group were found to be useful.Both Mds and Pme show considerable resistance to TFA and, therefore, are suitable for procedures in which the intermediates are deprotected by TFA treatment, while Mtr is the most useful protecting group when TFA treatment is not necessary.Keywords---4-methoxy-2,6-dimethylbenzenesulfonyl (Mds); 2,4,6-trimethoxybenzenesulfonyl (Mtb); 2,3,4,5,6-pentamethylbenzenesulfonyl (Pme); 4-methoxy-2,3,6-trimethylbenzenesulfonyl (Mtr); trifluoroacetic acid-thioanisole deprotection