80876-58-0 Usage
Description
L-Idaric acid, also known as L-2-(+)-tartaric acid, is an organic compound with the chemical formula C4H6O6. It is a chiral molecule, meaning it has a non-superimposable mirror image, and is one of the isomers of tartaric acid. L-Idaric acid is an off-white solid and is useful in organic synthesis.
Uses
Used in Organic Synthesis:
L-Idaric acid is used as a chiral building block in organic synthesis for the production of various pharmaceuticals, agrochemicals, and other specialty chemicals. Its unique stereochemistry allows for the creation of enantiomerically pure compounds, which are essential in many applications, particularly in the pharmaceutical industry where the desired biological activity is often associated with a specific enantiomer.
Used in Pharmaceutical Industry:
L-Idaric acid is used as an intermediate in the synthesis of certain drugs, particularly those that require chiral centers. Its ability to form stable derivatives with other molecules makes it a valuable component in the development of new pharmaceuticals with improved efficacy and selectivity.
Used in Chiral Catalysts:
L-Idaric acid can be used as a chiral catalyst in asymmetric reactions, where it helps to control the stereochemistry of the products formed. This is particularly important in the synthesis of enantiomerically pure compounds, as it allows for the selective formation of one enantiomer over the other.
Used in Analytical Chemistry:
L-Idaric acid can be used as a chiral resolving agent in chromatographic techniques, such as high-performance liquid chromatography (HPLC) and gas chromatography (GC). It helps to separate enantiomers by interacting with them in a stereoselective manner, allowing for the analysis and quantification of individual enantiomers in a mixture.
Check Digit Verification of cas no
The CAS Registry Mumber 80876-58-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,0,8,7 and 6 respectively; the second part has 2 digits, 5 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 80876-58:
(7*8)+(6*0)+(5*8)+(4*7)+(3*6)+(2*5)+(1*8)=160
160 % 10 = 0
So 80876-58-0 is a valid CAS Registry Number.
80876-58-0Relevant articles and documents
SYNTHESIS OF L-IDARO-1,4-LACTONE, AN INHIBITOR OF α-L-IDOSID-URONASE
Herd, J. Kenneth,Mayberry, William R.,Snell, Robert L.
, p. 33 - 40 (2007/10/02)
L-Idaro-1,4-lactone was synthesized by two different, published methods: (1) epimerization of monopotassium D-glucarate by refluxing in aqueous barium hydroxide, and (2) oxidation of L-iditol by heating in dilute nitric acid.The lactone, formed by heat dehydration from aqueous solution at low pH, was purified by paper chromatography, and quantitated by gas-liquid chromatography using inositol as the internal standard.The monolactone inhibited human, seminal-fluid α-L-idosiduronase activity, with either phenyl or 4-methylumbelliferyl α-L-idosiduronic acid as the substrate, to the same degree as D-glucaro-1,4-lactone inhibits α-D-glucosiduranose.
