81087-77-6

Basic information

• Product Name: 1-tert-Butoxycarbonylmethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester
• Synonyms: 1-tert-Butoxycarbonylmethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester
• CAS NO: 81087-77-6
• Molecular Weight: 486.952
• Mol File: 81087-77-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-tert-Butoxycarbonylmethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-tert-Butoxycarbonylmethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester(81087-77-6)
• EPA Substance Registry System: 1-tert-Butoxycarbonylmethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester(81087-77-6)

Safety Data

• Hazardous Substances Data: 81087-77-6(Hazardous Substances Data)

Upstream product

• 67467-27-0 2-amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acid 
• 3320-83-0 o-chlorophenyl isocyanate 
• 107-59-5 tert-Butyl chloroacetate 
• 81087-59-4 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H,3H)-quinazolinedione 

Downstream Products

• 136743-94-7 1-Carboxymethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-67-4 1-carbamoylmethyl-3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)-quinazolinedione 
• 81088-41-7 3-(2-Chloro-phenyl)-5,7-dimethyl-1-methylcarbamoylmethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-62-9 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-(N,N-diethyl)aminocarbonylmethyl-2,4(1H, 3H)-quinazolinedione 
• 136743-97-0 3-(2-Chloro-phenyl)-1-(2-dimethylamino-ethoxycarbonylmethyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81088-49-5 3-(2-Chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1-(2-oxo-2-piperidin-1-yl-ethyl)-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-68-5 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-1-(N-methylpiperazino)acetyl-2,4(1H,3H)-quinazolinedione 
• 81088-39-3 1-[(Benzyl-methyl-carbamoyl)-methyl]-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81088-28-0 3-(2-Chloro-phenyl)-1-(3-dimethylamino-propoxycarbonylmethyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride 
• 81088-25-7 3-(2-Chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1-(2-piperidin-1-yl-ethoxycarbonylmethyl)-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride 

Relevant articles and documents

Studies on hypotensive agents. Synthesis of 1-substituted 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)- quinazolinediones

3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)- quinazolinedione was newly prepared. 1-Hydrogen atoms of the compound were variously substituted in order to test for their hypotensive activities on relaxing effects of the blood vessels. The compounds with 2-(1-pyrrolidinyl ethyl, 2-(1-piperidinyl)ethyl, 3-(dimethylamino)propyl, and 3-(N-benzyl-N-methylamino)propyl moieties showed significant activity. The 2-(1-piperidinyl)ethyl compound possessed activity approximately 23 times more potent than papaverine, however, it was less potent than cinnarizine.