81088-28-0

Basic information

• Product Name: 3-(2-Chloro-phenyl)-1-(3-dimethylamino-propoxycarbonylmethyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride
• CAS NO: 81088-28-0
• Molecular Weight: 552.455
• Mol File: 81088-28-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-Chloro-phenyl)-1-(3-dimethylamino-propoxycarbonylmethyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-Chloro-phenyl)-1-(3-dimethylamino-propoxycarbonylmethyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride(81088-28-0)
• EPA Substance Registry System: 3-(2-Chloro-phenyl)-1-(3-dimethylamino-propoxycarbonylmethyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester; hydrochloride(81088-28-0)

Safety Data

• Hazardous Substances Data: 81088-28-0(Hazardous Substances Data)

Upstream product

• 81087-77-6 1-tert-Butoxycarbonylmethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 136743-94-7 1-Carboxymethyl-3-(2-chloro-phenyl)-5,7-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-quinazoline-6-carboxylic acid ethyl ester 
• 81087-59-4 3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4-(1H,3H)-quinazolinedione 
• 67467-27-0 2-amino-5-ethoxycarbonyl-4,6-dimethylbenzoic acid 
• 3320-83-0 o-chlorophenyl isocyanate 
• 3179-63-3 3-Dimethylamino-1-propanol 

Relevant articles and documents

Studies on hypotensive agents. Synthesis of 1-substituted 3-(2-chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)- quinazolinediones

3-(2-Chlorophenyl)-6-ethoxycarbonyl-5,7-dimethyl-2,4(1H,3H)- quinazolinedione was newly prepared. 1-Hydrogen atoms of the compound were variously substituted in order to test for their hypotensive activities on relaxing effects of the blood vessels. The compounds with 2-(1-pyrrolidinyl ethyl, 2-(1-piperidinyl)ethyl, 3-(dimethylamino)propyl, and 3-(N-benzyl-N-methylamino)propyl moieties showed significant activity. The 2-(1-piperidinyl)ethyl compound possessed activity approximately 23 times more potent than papaverine, however, it was less potent than cinnarizine.