81097-32-7Relevant articles and documents
Synthetic Studies of Haliclonin A: Construction of the 3-Azabicyclo[33.1]nonane Skeleton with a Bridge that Forms the 17-Membered Ring
Orihara, Kensuke,Kawagishi, Fumiki,Yokoshima, Satoshi,Fukuyama, Tohru
, p. 769 - 772 (2018)
The core structure of haliclonin A, a 3-azabicyclo[3.3.1]nonane with a bridge that forms a 17-membered ring, was constructed. The synthesis features a ring-closing metathesis that constructs the macrocyclic ring, the stereoselective introduction of carbon units via the intramolecular cyclopropanation of a diazoester, the conjugate addition of an organocopper reagent, and the formation of 3-azabicyclo [3.3.1] nonane skeleton via an unexpected 1,5-hydride shift.
Rhodium(III)-Catalyzed Synthesis of Skipped Enynes via C(sp3)–H Alkynylation of Terminal Alkenes
Della-Felice, Franco,Zanini, Margherita,Jie, Xiaoming,Tan, Eric,Echavarren, Antonio M.
supporting information, p. 5693 - 5698 (2021/02/09)
The RhIII-catalyzed allylic C?H alkynylation of non-activated terminal alkenes leads selectively to linear 1,4-enynes at room-temperature. The catalytic system tolerates a wide range of functional groups without competing functionalization at other positions. Similarly, the vinylic C?H alkynylation of α,β- and β,γ- unsaturated amides gives conjugated Z-1,3-enynes and E-enediynes.
Iron-Catalyzed Synthesis of α-Dienyl Five- and Six-Membered N-Heterocycles
Gonnard, Laurine,Guérinot, Amandine,Cossy, Janine
, p. 6160 - 6167 (2017/11/15)
The iron-catalyzed synthesis of α-dienyl N-heterocycles is reported. The method is cost-effective, atom-economic, and led to a range of substituted α-dienyl heterocycles in moderate to good yields and diastereoselectivities. The α-dienyl piperidines are key synthetic intermediates as demonstrated by the preparation of a panel of α-polyenyl N-heterocycles.
