81111-96-8

Basic information

• Product Name: (+)-2-methanesulfonyloxy-1-(4-isobutylphenyl)-1-propanone dimethyl acetal
• Synonyms: (+)-2-methanesulfonyloxy-1-(4-isobutylphenyl)-1-propanone dimethyl acetal
• CAS NO: 81111-96-8
• Molecular Weight: 330.445
• Mol File: 81111-96-8.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (+)-2-methanesulfonyloxy-1-(4-isobutylphenyl)-1-propanone dimethyl acetal(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-2-methanesulfonyloxy-1-(4-isobutylphenyl)-1-propanone dimethyl acetal(81111-96-8)
• EPA Substance Registry System: (+)-2-methanesulfonyloxy-1-(4-isobutylphenyl)-1-propanone dimethyl acetal(81111-96-8)

Safety Data

• Hazardous Substances Data: 81111-96-8(Hazardous Substances Data)

Upstream product

• 83022-32-6 (RS)-2-hydroxy-1,1-dimethoxy-1-(4'-isobutylphenyl)propane 
• 124-63-0 methanesulfonyl chloride 

Downstream Products

• 15687-27-1 ibuprofen 
• 61566-34-5 (+/-)-ibuprofen methyl ester 

Relevant articles and documents

Manufacture of alpha-arylalkanoic acids and precursors

α-Arylalkanoic acids or esters, orthoesters or amides thereof are prepared by forming an α-hydroxy ketal or thioketal of an aryl alkyl ketone, activating the α-hydroxy substituent with an esterifying agent to form the corresponding ketal or thioketal ester substrate, wherein the ester group is sufficiently labile to non-catalytically disassociate from the substrate in a protic or dipolar, aprotic solvent, maintaining the ester substrate in contact with the protic or dipolar, aprotic solvent or mixtures thereof for a time sufficient to form the corresponding α-arylakanoic acid or ester, orthoester or amide thereof, and optionally concomitantly or sequentially hydrolyzing any ester, orthoester or amide formed to the corresponding α-arylalkanoic acid.