83022-32-6

Basic information

• Product Name: (RS)-2-hydroxy-1,1-dimethoxy-1-(4'-isobutylphenyl)propane
• Synonyms: (RS)-2-hydroxy-1,1-dimethoxy-1-(4'-isobutylphenyl)propane
• CAS NO: 83022-32-6
• Molecular Weight: 252.354
• Mol File: 83022-32-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (RS)-2-hydroxy-1,1-dimethoxy-1-(4'-isobutylphenyl)propane(CAS DataBase Reference)
• NIST Chemistry Reference: (RS)-2-hydroxy-1,1-dimethoxy-1-(4'-isobutylphenyl)propane(83022-32-6)
• EPA Substance Registry System: (RS)-2-hydroxy-1,1-dimethoxy-1-(4'-isobutylphenyl)propane(83022-32-6)

Safety Data

• Hazardous Substances Data: 83022-32-6(Hazardous Substances Data)

Upstream product

• 538-93-2 1-phenyl-2-methylpropane 
• 141-52-6 sodium ethanolate 
• 105538-90-7 (S)-2-chloro-1-(4'-isobutylphenyl)propan-1-one 

Downstream Products

• 61566-34-5 (+/-)-ibuprofen methyl ester 
• 81111-96-8 (+)-2-methanesulfonyloxy-1-(4-isobutylphenyl)-1-propanone dimethyl acetal 
• 129159-24-6 1-fluoroethyl 4-isobutylphenyl ketone 
• 121071-96-3 1-methoxy-1-(4-isobutylphenyl)-2-propanone 

Relevant articles and documents

Zinc Salt Catalyzed Rearrangement of Acetals of Optically Active Aryl 1-Chloroethyl Ketones: Synthesis of Optically Active 2-Arylpropionic Acids and Esters

The preparation of (S)-2-(4'-isobutylphenyl)propionic acid ((S)-Ibuprofen) (82percent optical purity) and (S)-2-(6'-methoxy-2'-naphthyl)propionic acid (Naproxen) (96percent optical purity) has been accomplished by starting from optically pure (S)-2-chloropropionyl chloride.The investigation for finding the best experimental conditions and minimizing racemization phenomena is presented.