811861-59-3

Basic information

• Product Name: 1,13-Trioxa-SA-pTyr-γ-p-azidoGlu-Glu-Ile-OH
• Synonyms: 1,13-Trioxa-SA-pTyr-γ-p-azidoGlu-Glu-Ile-OH
• CAS NO: 811861-59-3
• Molecular Weight: 1051.06
• Mol File: 811861-59-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,13-Trioxa-SA-pTyr-γ-p-azidoGlu-Glu-Ile-OH(CAS DataBase Reference)
• NIST Chemistry Reference: 1,13-Trioxa-SA-pTyr-γ-p-azidoGlu-Glu-Ile-OH(811861-59-3)
• EPA Substance Registry System: 1,13-Trioxa-SA-pTyr-γ-p-azidoGlu-Glu-Ile-OH(811861-59-3)

Safety Data

• Hazardous Substances Data: 811861-59-3(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 4246-51-9 4,7,10-trioxa-1,13-diaminotridecane 
• 71989-18-9 Fmoc-Glu(OtBu)-OH 
• 147762-53-6 N-(fluorenylmethyloxycarbonyl)tyrosine-O-phosphate 
• 200616-39-3 Fmoc-Glu(2-phenylisopropyl)-OH 

Relevant articles and documents

ATP-phosphopeptide conjugates as inhibitors of Src tyrosine kinases

ATP-phosphopeptide conjugates were synthesized and evaluated in vitro against c-Src and Lck. A number of Src SH2 domain inhibitors enhance the kinase catalytic activity by switching the closed inactive to the open active conformation. ATP-phosphopeptide conjugates were designed and synthesized as Src tyrosine kinase inhibitors based on a tetrapeptide sequence pTyr-Glu-Glu-Ile (pYEEI) and ATP to block the SH2 domain signaling and substrate phosphorylation by ATP, respectively. In general, ATP-phosphopeptide conjugates with optimal linkers such as compounds 5 and 7 (Ki = 1.7-2.6 μM) showed higher binding affinities to the ATP-binding site relative to the other ATP-phosphopeptide conjugates having short or long linkers, 1-4 and 6, (K i = 10.1-16.1 μand ATP (Km = 74 μM). These ATP-phosphopeptide conjugates may serve as novel templates for designing protein tyrosine kinase inhibitors to block SH2 mediated protein-protein interactions and to counter the activation of enzyme that resulted from the SH2 inhibition.