147762-53-6 Usage
Description
Fmoc-O-Phospho-L-tyrosine, also known as Fmoc-Tyr(PO3H2)-OH, is a synthetic phosphoamino acid derivative that serves as a crucial building block in the field of peptide chemistry. It is characterized by its white to off-white powder form and is widely utilized in the development of various bioactive peptides and pharmaceutical compounds.
Uses
Used in Pharmaceutical Industry:
Fmoc-O-Phospho-L-tyrosine is used as a key component in the synthesis of bioactive peptides for the pharmaceutical industry. Its incorporation into peptide structures allows for the creation of molecules with specific biological activities, making it a valuable tool in drug discovery and development.
Used in Research and Development:
In the research and development sector, Fmoc-O-Phospho-L-tyrosine is employed as a building block for the synthesis of phosphopeptides, which are essential in understanding the role of phosphorylation in cellular signaling pathways. This knowledge can lead to the development of targeted therapies for various diseases.
Used in Synthesis of Specific Bioactive Peptides:
Fmoc-O-Phospho-L-tyrosine is used as a synthetic building block for the creation of specific bioactive peptides, such as an asparagine mimetic-containing phosphopeptide that acts as an antagonist of the Grb2-SH2 domain. This application is particularly relevant in the study of protein-protein interactions and the development of novel therapeutic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 147762-53-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,7,7,6 and 2 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 147762-53:
(8*1)+(7*4)+(6*7)+(5*7)+(4*6)+(3*2)+(2*5)+(1*3)=156
156 % 10 = 6
So 147762-53-6 is a valid CAS Registry Number.
InChI:InChI=1/C24H22NO8P/c26-23(27)22(13-15-9-11-16(12-10-15)33-34(29,30)31)25-24(28)32-14-21-19-7-3-1-5-17(19)18-6-2-4-8-20(18)21/h1-12,21-22H,13-14H2,(H,25,28)(H,26,27)(H2,29,30,31)/t22-/m0/s1
147762-53-6Relevant articles and documents
An in situ Dynamic Continuum of Supramolecular Phosphoglycopeptides Enables Formation of 3D Cell Spheroids
Wang, Huaimin,Shi, Junfeng,Feng, Zhaoqianqi,Zhou, Rong,Wang, Shiyu,Rodal, Avital A.,Xu, Bing
, p. 16297 - 16301 (2017)
Higher-order assemblies of proteins, with a structural and dynamic continuum, is an important concept in biology, but these insights have yet to be applied in designing biomaterials. Dynamic assemblies of supramolecular phosphoglycopeptides (sPGPs) transf
Enzyme Instructed Self-assembly of Naphthalimide-dipeptide: Spontaneous Transformation from Nanosphere to Nanotubular Structures that Induces Hydrogelation
Chakravarthy, Rajan Deepan,Lin, Hsin-Chieh,Mohammed, Mohiuddin
, (2020/08/03)
Understanding the structure-morphology relationships of self-assembled nanostructures is crucial for developing materials with the desired chemical and biological functions. Here, phosphate-based naphthalimide (NI) derivatives have been developed for the
A general and convenient synthesis of novel phosphotyrosine mimetics
Szardenings, Anna Katrin,Gordeev, Mikhail F.,Patel, Dinesh V.
, p. 3635 - 3638 (2007/10/03)
A simple and general procedure for preparation of various phosphotyrosine mimetics from the corresponding phenolic precursors is described. In situ silylation of phenol acids followed by treatment with Et3N/CBr4/HP(O)(OEt)2 provides diethyl phosphate intermediates (36-96%), which can be cleanly deprotected in quantitative yields upon treatment with BSTFA/TMSI to afford novel phosphotyrosine mimetics.
