81190-89-8

Basic information

• Product Name: 1H-Pyrazole-3-carboxylic acid, 4-bromo-, methyl ester
• Synonyms: 4-Bromo-3-(methoxycarbonyl)-1H-pyrazole, Methyl 4-bromo-1H-pyrazole-5-carboxylate;Methyl 3-broMo-1H-pyrazole-4-carboxylate;4-broMopyrazole-3-carboxylic acid Methyl ester;1H-Pyrazole-3-carboxylic acid, 4-bromo-, methyl ester;4-BROMO-1H-PYRAZOLE-3-CARBOXYLICACIDMETHYLESTER;methyl 4-bromo-1H-pyrazole-3-carboxylate;methyl 4-bromo-1H-pyrazole-5-carboxylate(SALTDATA: FREE)
• CAS NO: 81190-89-8
• Molecular Formula: C₅H₅BrN₂O₂
• Molecular Weight: 205.02
• Product Categories: Building Blocks;Pyrazole
• Mol File: 81190-89-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 318℃
• Flash Point: 146℃
• Appearance: /
• Density: 1.781
• Storage Temp.: 2-8°C
• PKA: 9.75±0.50(Predicted)
• CAS DataBase Reference: 1H-Pyrazole-3-carboxylic acid, 4-bromo-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrazole-3-carboxylic acid, 4-bromo-, methyl ester(81190-89-8)
• EPA Substance Registry System: 1H-Pyrazole-3-carboxylic acid, 4-bromo-, methyl ester(81190-89-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 81190-89-8(Hazardous Substances Data)

Usage

Uses

Methyl 4-bromo-1H-pyrazole-3-carboxylate is a carboxylic acid ester organic compound, mainly used as a pharmaceutical intermediate.

Upstream product

• 190263-45-7 2-Benzenesulfonyl-4-bromo-2H-pyrazole-3-carboxylic acid methyl ester 

Downstream Products

• 138786-91-1 1-((2R,3R,4R,5R)-3,4-Bis-benzoyloxy-5-benzoyloxymethyl-tetrahydro-furan-2-yl)-4-bromo-1H-pyrazole-3-carboxylic acid methyl ester 
• 1445891-15-5 methyl 4-(2-chlorophenyl)-1-(2-chloropyridin-4-yl)-1H-pyrazole-3-carboxylate 
• 1445891-12-2 methyl 4-(2-chlorophenyl)-1H-pyrazole-3-carboxylate 
• 514816-42-3 4-bromo-2-methyl-2H-pyrazole-3-carboxylic acid methyl ester 
• 211738-66-8 4-bromo-1-methyl-1H-pyrazole-3-carboxylic acid methyl ester 
• 23097-85-0 methyl 2-methyl-4-phenyl-2H-pyrazole-3-carboxylate 
• 5932-28-5 4-phenyl-1H-pyrazole-3-carboxylic acid methyl ester 

Relevant articles and documents

ARYL AND HETEROARYL-CARBOXAMIDE SUBSTITUTED HETEROARYL COMPOUNDS AS TYK2 INHIBITORS

Novel carboxamide substituted compounds of Formula (I) are disclosed; as well as processes for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Tyrosine Kinase 2 (Tyk2).