81402-52-0

Basic information

• Product Name: Benzenepropanol, g-(dimethylamino)-
• CAS NO: 81402-52-0
• Molecular Formula: C11H17NO
• Molecular Weight: 179.262
• Mol File: 81402-52-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: Benzenepropanol, g-(dimethylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenepropanol, g-(dimethylamino)-(81402-52-0)
• EPA Substance Registry System: Benzenepropanol, g-(dimethylamino)-(81402-52-0)

Safety Data

• Hazardous Substances Data: 81402-52-0(Hazardous Substances Data)

Usage

General Description

Benzenepropanol, g-(dimethylamino)- is a chemical compound that is also known as dimethylamino benzyl alcohol. It is a colorless liquid with a mild, pleasant odor. Benzenepropanol, g-(dimethylamino)- is commonly used as a solvent, in the formulation of perfumes and as a precursor in the synthesis of pharmaceuticals and other organic compounds. It is also used as a reagent in chemical research and as a stabilizer in the manufacture of plastics and polymers. However, it is important to handle this compound with care as it can be harmful if it comes into contact with the skin or is ingested, and it should only be used in well-ventilated areas to prevent inhalation of its vapors.

Upstream product

• 100-52-7 benzaldehyde 
• 50-00-0 formaldehyd 
• 64-18-6 formic acid 
• 14593-04-5 3-amino-3-phenyl-1-propanol 
• 3646-50-2 3-Amino-3-phenylpropionic acid 
• 82769-74-2 (R)-(-)-3-(dimethylamino)-3-phenyl-1-propanol 
• 82769-75-3 (S)-(+)-3-(dimethylamino)-3-phenyl-1-propanol 
• 6098-50-6 3-dimethylamino-3-phenylpropionic acid 
• 85608-26-0 Winterstein acid hydrochloride 
• 24892-67-9 3-Dimethylamino-3-phenyl-propionsaeureethylester 
• 220437-96-7 methyl 2-<(trimethylsilyl)methyl>amino-2-phenylacetate 
• 15028-40-7 DL-2-phenylglycine methyl ester hydrochloride 
• 3585-33-9 lithium dimethylamide 
• 4192-77-2 ethyl cinnamate 

Downstream Products

• 1119825-22-7 C₁₄H₂₂N₂O₂ 
• 1353585-50-8 (+)-3-N,N-dimethylamino-3-phenylpropanol L-tartaric acid salt 
• 119356-77-3 dapoxetine 
• 1071929-03-7 Dapoxetine hydrochloride 
• 82769-75-3 (S)-(+)-3-(dimethylamino)-3-phenyl-1-propanol 
• 1448512-87-5 S-(+)-N,N-dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine tartrate 
• 119356-76-2 N,N-dimethylamino-3-(naphthyl-1-oxy)-1-phenylprop-1-amine 
• 21040-45-9 Cinnamyl acetate 

Relevant articles and documents

Synthesis, separation-purification, and salt forming method of dapoxetine

The invention provides a novel synthesis, gradient separation-purification, and salt forming method of dapoxetine. Easily available and cheap benzaldehyde is taken as the primary raw material of the synthesis route. The whole reaction conditions are mild. The synthesis route is short. No highly toxic or explosive raw material is used. The problem of chiral separation is well solved in the route. During the separation process, the product is purified. Finally, chlorinated hydromethyl tert-butyl ether which does not have any side or toxic effect is used to carry out salt forming. A large amount of labor, material, and time is saved. The production cost is reduced. The synthesis does not need any special equipment. The operation is simple and convenient. The method has a good industrial application prospect.

A S - west reaches anchors the sandbank and its salt synthesis method

The invention discloses a synthetic method for S-dapoxetine. The synthetic method comprises the following steps: (1) resolving 1-phenyl-3-(naphthyl-1-oxy)propylamine for at least once with a resolving agent to obtain a resolved mixed system; (2) separating the resolved mixed system to obtain S-1-phenyl-3-(naphthyl-1-oxy)propylamine, and recycling mother liquor; (3) performing methylation on the S-1-phenyl-3-(naphthyl-1-oxy)propylamine to obtain S-dapoxetine. Compared with the conventional industrial production method, residual intermediate (R)-phenyl-3-(naphthyl-1-oxy)propylamine in the resolved mother liquor is firstly recycled on the basis of the prior art, then resolved again through D-(-) tartaric acid after racemization, and recycled, so that the yield is increased, the product waste is avoided, and the economic benefits are improved.