82769-75-3

Basic information

• Product Name: (S)-3-Dimethylamino-3-phenylpropanol
• Synonyms: (S)-3-Dimethylamino-3-phenylpropanol;(S)-3-(diMethyl aMino)-3-phenylpropan-1-ol;(3S)-3-(DiMethylaMino)-3-phenyl-1-propanol;Benzenepropanol, g-(diMethylaMino)-, (gS)-
• CAS NO: 82769-75-3
• Molecular Formula: C₁₁H₁₇NO
• Molecular Weight: 179.26
• Mol File: 82769-75-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 281 °C
• Flash Point: 98 °C
• Appearance: /
• Density: 1.011
• Refractive Index: 1.532
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 14.90±0.10(Predicted)
• CAS DataBase Reference: (S)-3-Dimethylamino-3-phenylpropanol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-Dimethylamino-3-phenylpropanol(82769-75-3)
• EPA Substance Registry System: (S)-3-Dimethylamino-3-phenylpropanol(82769-75-3)

Safety Data

• Hazardous Substances Data: 82769-75-3(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

Uses

(+)-(S)-3-[N,N-Dimethylamino)-3-phenylpropanol used in the preparation of 5-hydroxytryptamine reuptake inhibitors.

InChI:InChI=1/C11H17NO/c1-12(2)11(8-9-13)10-6-4-3-5-7-10/h3-7,11,13H,8-9H2,1-2H3/t11-/m0/s1

Upstream product

• 82769-77-5 (S)-(-)-3-methyl-4-phenyltetrahydro-1,3-oxazine 
• 82769-80-0 3-(dimethylamino)-2-<(4-methylphenyl)thio>-3-phenyl-1-propanol 
• 50-00-0 formaldehyd 
• 82769-76-4 (S)-3-amino-3-phenylpropanol 
• 3376-23-6 C-phenyl-N-methylnitrone 
• 82769-79-7 3-(dimethylamino)-2-<(4-methylphenyl)sulfinyl>-3-phenyl-1-propanol 
• 82769-70-8 (3S,4S)-2-Methyl-3-phenyl-4-((R)-toluene-4-sulfinyl)-isoxazolidine 
• 81402-52-0 3-(dimethylamino)-3-phenylpropan-1-ol 
• 85608-26-0 Winterstein acid hydrochloride 
• 6098-50-6 3-dimethylamino-3-phenylpropionic acid 
• 910560-67-7 (S)-3-dimethylamino-3-phenyl-propionic acid 
• 85608-26-0 3-dimethylamino-3-phenyl propionic acid hydrochloride 
• 1353585-50-8 (+)-3-N,N-dimethylamino-3-phenylpropanol L-tartaric acid salt 
• 82769-74-2 (R)-(-)-3-(dimethylamino)-3-phenyl-1-propanol 

Downstream Products

• 119356-77-3 dapoxetine 
• 1071929-03-7 Dapoxetine hydrochloride 
• 81402-52-0 3-(dimethylamino)-3-phenylpropan-1-ol 

Relevant articles and documents

Amino alcohols using the optically active amino alcohol derivative bi- Nord complex boron - -

Disclosed are an amino alcohol-boron-binol complex as an intermediate, including Complex 3-1-1 shown below, and a method for preparing an optically active amino alcohol by using the same, wherein a racemic amino alcohol is resolved in an enationselective manner using a boron compound and a (R)- or (S)-binol, whereby an amino alcohol derivative with high optical purity can be prepared at high yield.

5-hydroxytryptamine re-absorption inhibitor crystal form and preparation method thereof

The invention relates to a dapoxetine hydrochloride crystal form and a preparation method thereof, and belongs to the technical field of drug synthesis. The preparation method comprises: dissolving (S)-3-amino-3-phenylpropionic acid in an appropriate solvent, adding a reducing agent and a Lewis acid, and reducing to obtain (S)-3-amino-3-phenylpropanol; dissolving the (S)-3-amino-3-phenylpropanolin formic acid, and adding formaldehyde to produce (S)-3-dimethylamino-3-phenylpropanol; dissolving the (S)-3-dimethylamino-3-phenylpropanol in an organic solvent, adding an alkali and 1-fluoronaphthalene, carrying out heating stirring for 5-10 h, adding water and an organic solvent, extracting, carrying out spin drying on the organic phase, dissolving with a solvent, adding concentrated hydrochloric acid in a dropwise manner, and carrying out pressure reducing distillation to remove the solvent and the water; and re-crystallizing with a suitable solvent to obtain the dapoxetine hydrochloride.According to the present invention, the Cu-Ka radiation results of the obtained dapoxetine hydrochloride crystal form show that the characteristic peaks represented by 2[theta] angle are positioned at 6.24+/-0.2, 15.03+/-0.2, 18.87+/-0.2, 20.63+/-0.2 and 25.28+/-0.2 in the X-ray powder diffraction pattern.

A method for preparing west reaches anchors the sandbank hydrochloride (by machine translation)

The invention relates to the field of medicine, in particular to a method for preparing west reaches anchors the sandbank hydrochloride, specifically comprises the following steps: (1) in order to chiral L - phenylalanine ester hydrochloride as the starting material, the reduction to obtain intermediate II reduction system; (2) intermediate II poly formaldehyde or formaldehyde generating Eschweiler - Clark reaction, to obtain the intermediate III; (3) the intermediate III with 1 - fluorine naphthalene generating Williamson west reaches anchors the sandbankcheng Mi reaction to obtain the hydrochloride. The present invention relates to chiral L - phenylalanine ester hydrochloride as the raw material of the final product to avoid splitting, and the raw materials are easy to obtain, the price is relatively low, the conventional apparatus to meet the need of production, without the use of expensive, there is a toxic reagent, mild reaction conditions, pollution is small, easy to control, and is suitable for industrial production. (by machine translation)