81548-17-6Relevant articles and documents
Lipase-catalyzed resolution of chiral 1,3-amino alcohols: application in the asymmetric synthesis of (S)-dapoxetine
Torre, Oliver,Gotor-Fernandez, Vicente,Gotor, Vicente
, p. 860 - 866 (2007/10/03)
The enzymatic resolution of 3-amino-3-phenylpropan-1-ol derivatives has been studied through acylation processes. Candida antarctica lipase A (CAL-A) has been identified as the best biocatalyst for the transesterification reaction of 3-amino-3-phenyl-1-tert-butyldimethylsilyloxy-propan-1-ol using ethyl methoxyacetate as acylating agent and tert-butyl methyl ether as solvent. This enzymatic study has allowed us to obtain a valuable intermediate for the production of (S)-dapoxetine, which has been synthesized in good overall yield and high enantiomeric excess.
ADDITION OF NITRILES TO OXETANES
Pavel', T. M.
, p. 157 - 159 (2007/10/02)
The reaction of oxetanes with acrylonitrile and benzonitrile in the presence of concentrated sulfuric acid leads to the formation of the corresponding 5,6-dihydro-1,3-oxazines.