81601-68-5

Basic information

• Product Name: ((1R,2R,4S)-3,3-dimethylbicyclo[2.2.1]heptan-2-yl)methanol
• Synonyms: ((1R,2R,4S)-3,3-dimethylbicyclo[2.2.1]heptan-2-yl)methanol
• CAS NO: 81601-68-5
• Molecular Weight: 154.252
• Mol File: 81601-68-5.mol
• Article Data: 9

Chemical Properties

• CAS DataBase Reference: ((1R,2R,4S)-3,3-dimethylbicyclo[2.2.1]heptan-2-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: ((1R,2R,4S)-3,3-dimethylbicyclo[2.2.1]heptan-2-yl)methanol(81601-68-5)
• EPA Substance Registry System: ((1R,2R,4S)-3,3-dimethylbicyclo[2.2.1]heptan-2-yl)methanol(81601-68-5)

Safety Data

• Hazardous Substances Data: 81601-68-5(Hazardous Substances Data)

Upstream product

• 875-03-6 3,3-dimethyl-spiro[norbornan-2,2'-oxirane] 
• 542-92-7 cyclopenta-1,3-diene 
• 374895-87-1 C₁₀H₁₄O 
• 107-86-8 3,3-dimethyl acrylaldehyde 
• 565-00-4 dl-camphene 
• 79-92-5 camphene 
• 5056-10-0 acetic acid-(3,3-dimethyl-[2]norbornylidenemethyl ester) 
• 15780-34-4 1-(3,3-Dimethyl-bicyclo<2.2.1>hept-2-yl)ethanon 
• 15780-45-7 (+/-)-1-(3,3-dimethyl-norborn-5-ene-2-endo-yl)-ethanone 
• 20440-73-7 (+/-)-2,2-dimethyl-3-((Ξ)-nitromethylene)-norbornane of mp: 65 degree 
• 67519-00-0 2-exo-10-camphanoic acid 
• 875-03-6 (+/-)-camphene oxide 
• 85506-67-8 endo-2,2-dimethylbicyclo<2.2.1>heptane-3-carboxylic acid 

Downstream Products

• 81572-05-6 <α-2H2>benzyl camphyl thioether 
• 155227-27-3 C₂₅H₂₉NO₃ 
• 155227-25-1 C₂₀H₂₃NO₃ 
• 155323-17-4 (5S)-4-aza-2-oxa-6,6-dimethyl-7,10-methylene-5-spiro<4.5>decan-3-one 
• 94200-95-0 1-(3,3-Dimethyl-bicyclo<2.2.1>hept-2-yl)-2-methyl-propan-2-ol 
• 2226-08-6 2-(3,3-Dimethyl-bicyclo<2.2.1>hept-2-yl)-ethanol 
• 81601-69-6 tosylate of endo-camphanol 

Relevant articles and documents

A General Regioselective Synthesis of Alcohols by Cobalt-Catalyzed Hydrogenation of Epoxides

A straightforward methodology for the synthesis of anti-Markovnikov-type alcohols is presented. By using a specific cobalt triphos complex in the presence of Zn(OTf)2 as an additive, the hydrogenation of epoxides proceeds with high yields and selectivities. The described protocol shows a broad substrate scope, including multi-substituted internal and terminal epoxides, as well as a good functional-group tolerance. Various natural-product derivatives, including steroids, terpenoids, and sesquiterpenoids, gave access to the corresponding alcohols in moderate-to-excellent yields.

Preparation of polyfunctional phosphines using zinc organometallics

The reaction of functionalized diorganozincs with chlorodiorganophosphines provides polyfunctional phosphines in good yields. Especially attractive is the hydroboration/boron-zinc exchange sequence which allows the conversion of functionalized olefins into polyfunctional phosphines in a one-pot procedure. Several new chiral phosphines have been prepared starting from readily available chiral olefins (terpenes) and their efficiency in asymmetric hydrogenation reactions has been evaluated.

A Facile Conversion of Alkenes to Alcohols with Benzyltriethylammonium Borohydride-Chlorotrimethylsilane

A combination of benzyltrimethylammonium borohydride and chlorotrimethylsilane (1:1) in dichloromethane at 0 deg C has been found to be a convenient reagent system for the conversion of alkenes to alcohols, the hydroxy group of which is introduced in an anti-Markovnikov manner.