81932-03-8

Basic information

• Product Name: 1-Chloro-4-(difluoromethoxy)benzene
• Synonyms: 1-Chloro-4-(difluoromethoxy)benzene
• CAS NO: 81932-03-8
• Molecular Formula: C₇H₅ClF₂O
• Molecular Weight: 178.5638064
• Product Categories: Anisoles, Alkyloxy Compounds & Phenylacetates;Chlorine Compounds;Fluorine Compounds
• Mol File: 81932-03-8.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1-Chloro-4-(difluoromethoxy)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-4-(difluoromethoxy)benzene(81932-03-8)
• EPA Substance Registry System: 1-Chloro-4-(difluoromethoxy)benzene(81932-03-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 81932-03-8(Hazardous Substances Data)

Usage

General Description

1-Chloro-4-(difluoromethoxy)benzene, also known as 4-Chloro-1-(difluoromethoxy)benzene, is a synthetic, organic compound that belongs to the family of organochlorine and organofluorine compounds. Its molecular formula is C7H4ClF2O and it is characterized by a benzene ring substituted with difluoromethoxy and chloro groups. It is usually used as an intermediate in the synthesis of a wide range of pharmaceutical and agricultural chemicals. The compound is often chosen for its special properties, including good stability and reactivity. Due to its potential harmful effects on humans and the environment, the handling and disposal of this substance should be done carefully, usually in a controlled industrial environment.

Upstream product

• 75-45-6 Chlorodifluoromethane 
• 106-48-9 4-chloro-phenol 
• 104-88-1 4-chlorobenzaldehyde 
• 384-67-8 2-chloro-2,2-difluoroacetophenone 
• 930836-30-9 (chlorodifluoromethylsulfonyl)benzene 
• 403496-62-8 p-chlorophenyl chlorodifluoromethyl sulfone 
• 75-46-7 trifluoromethan 
• 1988-22-3 4-chlorophenyl formate 
• 33104-16-4 4-chlorophenyl dichloromethyl ether 
• 354-08-5 bromodifluoroacetic acid 
• 108-90-7 chlorobenzene 

Downstream Products

• 461-80-3 chlorodifluoromethyl p-chlorophenyl ether 
• 458-92-4 (difluoromethoxy)benzene 

Relevant articles and documents

Redox-Neutral TEMPO Catalysis: Direct Radical (Hetero)Aryl C?H Di- and Trifluoromethoxylation

Applications of TEMPO. catalysis for the development of redox-neutral transformations are rare. Reported here is the first TEMPO.-catalyzed, redox-neutral C?H di- and trifluoromethoxylation of (hetero)arenes. The reaction exhibits a broad substrate scope, has high functional-group tolerance, and can be employed for the late-stage functionalization of complex druglike molecules. Kinetic measurements, isolation and resubjection of catalytic intermediates, UV/Vis studies, and DFT calculations support the proposed oxidative TEMPO./TEMPO+ redox catalytic cycle. Mechanistic studies also suggest that Li2CO3 plays an important role in preventing catalyst deactivation. These findings will provide new insights into the design and development of novel reactions through redox-neutral TEMPO. catalysis.

DIFLUOROMETHOXYLATION AND TRIFLUOROMETHOXYLATION COMPOSITIONS AND METHODS FOR SYNTHESIZING SAME

The present invention provides a compound having the structure (I), a processing of making the compound; and a process of using the compound as a reagent for the difluoromethoxylation and trifluoromethoxylation of arenes or heteroarenes.

Xenon Difluoride Mediated Fluorodecarboxylations for the Syntheses of Di- and Trifluoromethoxyarenes

XeF2 is demonstrated to be a more proficient fluorine-transfer reagent than either NFSI or Selectfluor in fluorodecarboxylations of both mono- and difluoroaryloxy acetic acid derivatives. This method efficiently converts a wide range of neutral and electron-poor substrates to afford the desired di- and trifluoromethyl aryl ethers in good to excellent yields. The purifications are facile, and the reaction times are less than 5 min, which makes these fluorodecarboxylations promising for future PET-imaging applications.