82100-81-0Relevant articles and documents
Synthesis and antibacterial activity of some 4-(coumarin-3-yl)/Aryl 2 (3,5-dimethylpyrazol-1-yl)thiazoles
Aggarwal, Ranjana,Kumar, Sunil,Sharma, Chetan,Aneja, Kamal R.,Singh, Shiv P.
, p. 331 - 336 (2013/09/24)
Reaction of 3-(2-bromoacetyl) coumarins (4) with 3,5-dimethylpyrazol-1- thiocarboxamide (5) results in the formation of title compounds 6. 4-Aryl-2-(3,5-dimethylpyrazol-1-yl) thiazoles (8) which could not be synthesized earlier through this method, were obtained by performing the reaction in presence of a base. All the synthesized compounds have shown moderate to significant antibacterial activity against Gram-positive bacteria namely S. aureus and B. subtilis.
A facile one-pot synthesis of 2-pyrazolyl-4-aryl-thiazoles in a threecomponent reaction
Nalajam, Guravaiah,Vedula, Rajeswar Rao
experimental part, p. 195 - 197 (2009/08/07)
A one-pot multi-component reaction of phenacylbromide, thiosemicarbazide and acetyl acetone or ethyl acetoacetate is described for the preparation of the title compounds. The key features of this methodology are its operational simplicity, mild reaction conditions, and good yields.
Reported Formation of 3-Arylthiazolotriazepines in the Reaction of 2-Hydrazino-4-arylthiazoles with Pentane-2,4-dione: A Reinvestigation
Singh, S. P.,Diwakar, P.,Sehgal, Subhash,Vaid, R. K.
, p. 1054 - 1055 (2007/10/02)
The condensation of 2-hydrazino-4-arylthiazoles (1a-d) with pentane-2,4-dione (6) results in the formation of 2-(3',5'-dimethylpyrazol-1'-yl)-4-arylthiazoles (2a-d) and not the 3-arylthiazolotriazepines (3) as reported.The correct structural assignment is based on PMR, 13CNMR and high resolution mass spectrometry of the products (2a-d).These products have been obtained by an alternate route involving phenacyl bromides (4) and 3,5-dimethylpyrazol-1-thiocarboxamide (5).