82225-36-3

Basic information

• Product Name: 4-fluoro-N-(prop-2-yn-1-yl)benzamide
• CAS NO: 82225-36-3
• Molecular Formula: C₁₀H₈FNO
• Molecular Weight: 177.175
• Mol File: 82225-36-3.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 314.1°C at 760 mmHg
• Flash Point: 143.8°C
• Density: 1.175g/cm³
• Vapor Pressure: 0.000477mmHg at 25°C
• Refractive Index: 1.535
• CAS DataBase Reference: 4-fluoro-N-(prop-2-yn-1-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-fluoro-N-(prop-2-yn-1-yl)benzamide(82225-36-3)
• EPA Substance Registry System: 4-fluoro-N-(prop-2-yn-1-yl)benzamide(82225-36-3)

Safety Data

• Hazardous Substances Data: 82225-36-3(Hazardous Substances Data)

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 2450-71-7 Propargylamine 
• 1283075-99-9 dipropan-2-yl 1-(4-fluorobenzoyl)hydrazine-1,2-dicarboxylate 
• 459-57-4 4-fluorobenzaldehyde 
• 456-22-4 4-Fluorobenzoic acid 

Downstream Products

• 1201226-89-2 C₂₄H₂₆ClF₂N₅O₃ 
• 1212009-14-7 C₂₆H₂₀FN₃O₃ 
• 1212009-17-0 N-[2-(3,5-dibromo-2-pyridinyl)-10-oxo-2,10-dihydro-4aH-chromeno[3,2-c]pyridin-3-yl]methyl-4-fluorobenzenecarboxamide 
• 1214921-92-2 2-(4-fluorophenyl)-5-methylene-4,5-dihydrooxazole 
• 1310419-28-3 3-(4-((4-fluorobenzamido)methyl)-1H-1,2,3-triazol-1-yl)-2-(R,S)-hydroxypropyl 2,3,4,6-tetra-O-acetyl-α-D-galactopyranoside 
• 1410038-53-7 N-(buta-2,3-dienyl)-4-fluorobenzamide 

Relevant articles and documents

Rh(iii)-Catalyzed three-component cascade annulation to produce theN-oxopropyl chain of isoquinolone derivatives

Developing powerful methods to introduce versatile functional groups at theN-substituents of isoquinolone scaffolds is still a great challenge. Herein, we report a novel three-component cascade annulation reaction to efficiently construct theN-oxopropyl chain of isoquinolone derivativesviarhodium(iii)-catalyzed C-H activation/cyclization/nucleophilic attack, with oxazoles used both as the directing group and potential functionalized reagents.

Dual H-bond activation of NHC-Au(i)-Cl complexes with amide functionalized side-arms assisted by H-bond donor substrates or acid additives

Novel approach with amide-tethered H-bond donor NHC ligands enabled Au(i)-catalysis via H-bonding. The plain NHC-Au(i)-Cl complex catalysed conversions of terminal N-propynamides to oxazolines, and enyne cycloisomerization with an acid additive, in DCM at

Synthesis of 2,2,2-Trifluoroethyl Oxazoles, Oxazolines and Furans via Alkyne Oxytrifluoromethylation

This study reports an oxytrifluoromethylation method for construction of oxazoles and furans motif and the concurrent incorporation of a 2,2,2-trifluoroethyl group at the aromatic C5-position. High-valent copper(III) trifluoromethyl compounds are crucial