823829-27-2

Basic information

• Product Name: Ethanone, 1-(2,4-dimethoxyphenyl)-2-[(triphenylmethyl)thio]-
• CAS NO: 823829-27-2
• Molecular Formula: C29H26O3S
• Molecular Weight: 454.59
• Mol File: 823829-27-2.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Ethanone, 1-(2,4-dimethoxyphenyl)-2-[(triphenylmethyl)thio]-(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 1-(2,4-dimethoxyphenyl)-2-[(triphenylmethyl)thio]-(823829-27-2)
• EPA Substance Registry System: Ethanone, 1-(2,4-dimethoxyphenyl)-2-[(triphenylmethyl)thio]-(823829-27-2)

Safety Data

• Hazardous Substances Data: 823829-27-2(Hazardous Substances Data)

Upstream product

• 60965-26-6 2-Bromo-2',4'-dimethoxyacetophenone 
• 3695-77-0 triphenylmethanethiol 

Downstream Products

• 1619241-20-1 N-(4-(2,4-dimethoxyphenyl)thiazolidinyl)glycine 
• 1619241-19-8 C₁₇H₂₀N₂O₆S 
• 1537220-83-9 2-(1-(2,4-dimethoxyphenyl)-2-mercaptoethylamino)-N-(4-methyl-2-oxo-2H-chromen-7-yl)acetamide 
• 823829-31-8 N-(1-(2,4-dimethoxyphenyl)-2-S-tritylmercapto)ethylglycine 

Relevant articles and documents

Acid-sensitive auxiliary assisted atypical diubiquitin synthesis exploiting thiol-ene coupling

Atypical ubiquitin (Ub) chains are generally involved in intracellular physiological processes, while the molecular mechanisms underlying their regulation remain unclear. In this work, we report an acid-sensitive auxiliary group based bifunctional handle that can prepare Lys27-, Lys29- and Lys33-diUb analogs by thiol-ene coupling (TEC) in combination with native chemical ligation (NCL). A prominent advantage of this method is the rapid and effective removal of acid-sensitive auxiliary groups after the formation of the isopeptide bond mimic. Collectively, this work illustrates the utility of the new strategy in the simple and efficient production of homogeneous atypical diUb analogs for biochemical and biophysical studies.

Novel prothetic group connecting arm for synthesizing diubiquitin and synthesis method of diubiquitin

The invention discloses a novel prothetic group connecting arm for synthesizing diubiquitin and a synthesis method of the diubiquitin. The prothetic group connecting arm disclosed by the invention is loaded on protein through TEC (Triethyl Citrate) reaction and then is coupled with first-section ubiquitin through NCL; finally, a prothetic group is removed to obtain a ubiquitin chain based on a ubiquitin expression unit. According to the method disclosed by the invention, the disadvantage of a former technology that macromolecules are subjected to coupling reaction through TEC and the efficiency is low are overcome, and small molecules and the macromolecules are subjected to efficient reaction; a formed amide bond is closet to a natural isopeptide bond, so that a subsequent biochemical mechanism research is convenient to perform.

Native chemical ubiquitination using a genetically incorporated azidonorleucine

A robust chemical ubiquitination method was developed. The method employed a genetically incorporated azidonorleucine as an orthogonal lysine precursor for the installation of a Gly residue bearing an Nα-auxiliary which mediated the ligation between ubiquitin(1-75)-thioester and the target protein. To demonstrate our methodology, a model protein, K48-linked diubiquitin, was synthesized with an overall yield of 35%. the Partner Organisations 2014.