823829-31-8

Basic information

• Product Name: 2-[[1-(2,4-dimethoxyphenyl)-2-tritylsulfanylethyl]amino]acetic acid
• Synonyms: 2-[[1-(2,4-dimethoxyphenyl)-2-tritylsulfanylethyl]amino]acetic acid;N-(1-(2,4-dimethoxyphenyl)-2-S-tritylmercapto)ethylglycine
• CAS NO: 823829-31-8
• Molecular Formula: C31H31NO4S
• Molecular Weight: 513.64714
• Mol File: 823829-31-8.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 682.1±55.0 °C(Predicted)
• Appearance: /
• Density: 1.206±0.06 g/cm3(Predicted)
• PKA: 2.21±0.10(Predicted)
• CAS DataBase Reference: 2-[[1-(2,4-dimethoxyphenyl)-2-tritylsulfanylethyl]amino]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[[1-(2,4-dimethoxyphenyl)-2-tritylsulfanylethyl]amino]acetic acid(823829-31-8)
• EPA Substance Registry System: 2-[[1-(2,4-dimethoxyphenyl)-2-tritylsulfanylethyl]amino]acetic acid(823829-31-8)

Safety Data

• Hazardous Substances Data: 823829-31-8(Hazardous Substances Data)

Usage

Chemical compound

2-[[1-(2,4-dimethoxyphenyl)-2-tritylsulfanylethyl]amino]acetic acid is a chemical compound.

Used in organic synthesis and pharmaceutical research

It is used in organic synthesis and pharmaceutical research.

Derivative of amino acid

It is a derivative of amino acid.

Trityl protection group

It has a trityl protection group attached to the sulfur atom.

Molecule contains a 2,4-dimethoxyphenyl group

The molecule contains a 2,4-dimethoxyphenyl group.

Amino acid moiety

It contains an amino acid moiety.

Potential building block for synthesis of bioactive compounds

It is a potential building block for the synthesis of bioactive compounds.

Potential building block for peptide-based drugs

It is a potential building block for the synthesis of peptide-based drugs.

Trityl protection group provides stability to sulfur atom

The trityl protection group provides stability to the sulfur atom during chemical reactions.

Versatile intermediate in organic synthesis

It is a versatile intermediate in organic synthesis.

Potential applications in drug development

Its potential applications include the development of new drugs and pharmaceutical products.

Upstream product

• 823829-27-2 2-(S-trityl)mercapto-2’,4’-dimethoxyacetophenone 
• 56-40-6 glycine 
• 60965-26-6 2-Bromo-2',4'-dimethoxyacetophenone 
• 3695-77-0 triphenylmethanethiol 

Relevant articles and documents

Acid-sensitive auxiliary assisted atypical diubiquitin synthesis exploiting thiol-ene coupling

Atypical ubiquitin (Ub) chains are generally involved in intracellular physiological processes, while the molecular mechanisms underlying their regulation remain unclear. In this work, we report an acid-sensitive auxiliary group based bifunctional handle that can prepare Lys27-, Lys29- and Lys33-diUb analogs by thiol-ene coupling (TEC) in combination with native chemical ligation (NCL). A prominent advantage of this method is the rapid and effective removal of acid-sensitive auxiliary groups after the formation of the isopeptide bond mimic. Collectively, this work illustrates the utility of the new strategy in the simple and efficient production of homogeneous atypical diUb analogs for biochemical and biophysical studies.

Chemical Synthesis of Diubiquitin-Based Photoaffinity Probes for Selectively Profiling Ubiquitin-Binding Proteins

Biochemical studies of cellular processes involving polyubiquitin have gained increasing attention. More tools are needed to identify ubiquitin (Ub)-binding proteins. We report diazirine-based photoaffinity probes that can capture Ub-binding proteins in c

New semi-synthesis of ubiquitin C-terminal conjugate with 7-amino-4-methylcoumarin

The ligation of peptide hydrazides at a Gly site carrying a removal auxiliary was found to be an efficient process. This technology was successfully used for the synthesis of ubiquitin C-terminal conjugates. Recombinant Ub(1-75)-NHNH2 was prepared through the hydrozinolysis of the Ub(1-75)-intein fusion protein. It was ligated with a glycine derivative modified with an acid-sensitive thiol auxiliary. The final acid treatment produced the desired bioactive ubiquitin conjugates in practical quantities. Thus, the method described here extends the protocols of expressed protein ligation. Copyright 2013 European Peptide Society and John Wiley & Sons, Ltd. Native chemical ligation of a recombinant peptide hydrazide with a Gly-peptide carrying a removal auxiliary was examined and used to synthesize ubiquitin C-terminal conjugates. Copyright