824-53-3

Basic information

• Product Name: (2-bromo-4-methylphenyl)methanol
• Synonyms: (2-bromo-4-methylphenyl)methanol;2-Bromo-4-methylbenzyl alcohol;Benzenemethanol, 2-bromo-4-methyl-
• CAS NO: 824-53-3
• Molecular Formula: C₈H₉BrO
• Molecular Weight: 201.06046
• Mol File: 824-53-3.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (2-bromo-4-methylphenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-bromo-4-methylphenyl)methanol(824-53-3)
• EPA Substance Registry System: (2-bromo-4-methylphenyl)methanol(824-53-3)

Safety Data

• Hazardous Substances Data: 824-53-3(Hazardous Substances Data)

Usage

Uses

(2-Bromo-4-methylphenyl)methanol is used in preparation of 6,7-Dihydro-5H-diphenyl[a,c]cyclohepten-5-one compounds.

Upstream product

• 7697-27-0 2-bromo-4-methylbenzoic acid 
• 824-54-4 2-bromo-4-methylbenzaldehyde 
• 88174-23-6 2,6-dibromo-4-methylbenzaldehyde 

Downstream Products

• 75366-14-2 1-(bromomethyl)-2-bromo-4-methylbenzene 
• 909034-71-5 tert-butyl 4-hydroxy-4-[2-(hydroxymethyl)-5-methylphenyl]piperidine-1-carboxylate 
• 1300038-68-9 2-(2-bromo-4-methylbenzyl)-2-nitrocyclohexanone 
• 1300038-74-7 2-(2-bromo-4-methylbenzyl)-2-nitrocycloheptanone 
• 1300038-81-6 2-(2-bromo-4-methylbenzyl)-2-nitrocyclooctanone 
• 1300038-61-2 2-bromo-1-iodomethyl-4-methylbenzene 
• 1346964-52-0 1-(2-bromo-4-methylphenyl)pent-4-en-2-one 
• 1346964-68-8 (Z)-1-(2-bromo-4-methylphenyl)pent-3-en-2-one 
• 1346964-85-9 (E)-1-(2-bromo-4-methylphenyl)pent-3-en-2-one 
• 1069114-80-2 (2-bromo-4-methyl-phenyl)-acetonitrile 
• 1380541-11-6 2-(2-bromo-4-methylphenyl)-2-isopropyl-3-methylbutanenitrile 
• 1380541-18-3 C₁₅H₁₉Br₂N 
• 1380541-19-4 2-(2-bromo-4-(phenoxymethyl)phenyl)-2-isopropyl-3-methylbutanenitrile 
• 1380541-20-7 (1R,2R)-1-isopropyl-2-methyl-5-(phenoxymethyl)-2,3-dihydro-1H-indene-1-carbonitrile 

Relevant articles and documents

PYRIDO-PYRIMIDINONE AND PTERIDINONE COMPOUNDS AS INHIBITORS OF ENDORIBONUCLEASE INOSITOL REQUIRING ENZYME I (IRE I ALPHA) FOR THE TREATMENT OF CANCER DISEASES.

Described herein are pyrido-pyrimidinone and pteridinone compounds or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods treating cancer, alone and in combination with other therapeutic agents.

Morita-Baylis-Hillman Reaction of β,β-Disubstituted Enones: An Enantioselective Organocatalytic Approach for the Synthesis of Cyclopenta[b]annulated Arenes and Heteroarenes

The first enantioselective organocatalytic intramolecular Morita-Baylis-Hillman (MBH) reaction of sterically highly demanding β,β-disubstituted enones is presented. The MBH reaction of β,β-disubstituted-α,β-unsaturated electron-withdrawing systems was previously considered to be unfeasible. Towards this end, designer substrates, which under simple and practical reaction conditions generate a variety of cyclopenta[b]annulated arenes and heteroarenes in excellent enantiopurities and near-quantitative yields in remarkably short reaction times, are described. The reason for the unusually facile nature of this reaction is attributed to the synergy guided and entropically favored intramolecular reaction. Further, this strategy provides easy access to a substantial number of bioactive natural products and pharmaceutically significant compounds.

Bismuth-catalyzed synthesis of anthracenes via cycloisomerization of o-alkynyldiarylmethane

In this study, anthracenes were efficiently synthesized from o-alkynyldiarylmethane using a novel method that exploits the synergistic effect between Bi(OTf)3 as the catalyst, and trifluoroacetic acid (TFA). Through this reaction, we achieved the rapid and efficient synthesis of anthracenes bearing various functional groups under mild conditions.