82475-57-8

Basic information

• Product Name: N,N-bis(2-chloroethyl)-1,1,1-trimethylsilanamine
• Synonyms: N,N-Bis(2-chloroethyl)(trimethyl)silanamine; N,N-Bis(2-chloroethyl)-N-trimethylsilylamine
• CAS NO: 82475-57-8
• Molecular Formula: C₇H₁₇Cl₂NSi
• Molecular Weight: 214.2081
• Mol File: 82475-57-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 213.7°C at 760 mmHg
• Flash Point: 83°C
• Density: 1.02g/cm³
• Vapor Pressure: 0.236mmHg at 25°C
• Refractive Index: 1.452
• CAS DataBase Reference: N,N-bis(2-chloroethyl)-1,1,1-trimethylsilanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-bis(2-chloroethyl)-1,1,1-trimethylsilanamine(82475-57-8)
• EPA Substance Registry System: N,N-bis(2-chloroethyl)-1,1,1-trimethylsilanamine(82475-57-8)

Safety Data

• Hazardous Substances Data: 82475-57-8(Hazardous Substances Data)

Usage

General Description

N,N-bis(2-chloroethyl)-1,1,1-trimethylsilanamine is a chemical compound that is used as an alkylating agent in the treatment of cancer. It works by attaching alkyl groups to the DNA of cancer cells, preventing them from dividing and ultimately leading to their destruction. N,N-bis(2-chloroethyl)-1,1,1-trimethylsilanamine is a member of the nitrogen mustard family, which is known for its powerful anti-cancer properties. However, it is also highly toxic and can cause significant side effects, making it crucial for this chemical to be handled with extreme care. Additionally, it is important for healthcare professionals to closely monitor patients receiving treatment with this compound to manage any potential adverse effects. Overall, N,N-bis(2-chloroethyl)-1,1,1-trimethylsilanamine has shown promise as an effective anti-cancer agent, but its use requires careful consideration and supervision.

Upstream product

• 75-77-4 chloro-trimethyl-silane 
• 334-22-5 N,N-bis(chloro-2-ethyl)amine 

Downstream Products

• 82475-74-9 O-trimethylsilyl-N,N-bis(2-chloroethyl)carbamate 
• 131890-26-1 bis[2-(di-iso-propylphosphino)ethyl]amine 
• 66534-97-2 bis(2-(diphenylphosphino)ethyl)amine hydrochloride 
• 550373-32-5 bis[2-(dicyclohexylphosphanyl)ethyl]amine 
• 944710-34-3 bis[2-(di-tert-butylphosphino)ethyl]amine 

Relevant articles and documents

Synthesis, hydrolytic reactivity, and anticancer evaluation of N-and O-triorganosilylated compounds as new types of potential prodrugs

N- and O-Triorganosilylated compounds related to various anticancer agents were synthesized for evaluation as potential anticancer prodrugs. 1H-NMR and UV kinetic measurements of hydrolytic desilylation were used to correlate relative rates of structural unmasking with steric bulk about the silicon reaction center. The tert-butyldimethylsilyl ester of chlorambucil and a number of O-triorganosilylated carbamate derivatives of nor-nitrogen mustard showed significant activity against P-388 lymphocytic leukemia in mice.