550373-32-5

Basic information

• Product Name: Bis[2-(dicyclohexylphosphino)ethyl]amine, min. 97%
• Synonyms: Bis[2-(dicyclohexylphosphino)ethyl]amine, min. 97%;Bis[2-(dicyclohexylphosphino)ethyl]aMine;Bis[2-(dicyclohexylphosphino)ethyl]aMine, 97+%;2-dicyclohexylphosphanyl-N-(2-dicyclohexylphosphanylethyl)ethanamine
• CAS NO: 550373-32-5
• Molecular Formula: C₂₈H₅₃NP₂
• Molecular Weight: 465.674642
• Product Categories: Achiral Phosphine;Alkyl Phosphine
• Mol File: 550373-32-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 64-69℃
• Boiling Point: 578.2±39.0 °C(Predicted)
• Appearance: white/solid
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.01±0.19(Predicted)
• Water Solubility: Insoluble in water.
• Sensitive: Air Sensitive
• CAS DataBase Reference: Bis[2-(dicyclohexylphosphino)ethyl]amine, min. 97%(CAS DataBase Reference)
• NIST Chemistry Reference: Bis[2-(dicyclohexylphosphino)ethyl]amine, min. 97%(550373-32-5)
• EPA Substance Registry System: Bis[2-(dicyclohexylphosphino)ethyl]amine, min. 97%(550373-32-5)

Safety Data

• RIDADR: UN 3335
• WGK Germany: 3
• HazardClass: 8
• Hazardous Substances Data: 550373-32-5(Hazardous Substances Data)

Usage

Uses

It is used as a pharmaceutical intermediate.

Upstream product

• 55-86-7 mechlorethamine hydrochloride 
• 829-84-5 dicyclohexylphosphane 
• 82475-57-8 N,N-bis(2-chloroethyl)-1,1,1-trimethylsilylamine 

Downstream Products

• 550373-30-3 [CrCl₃(C₆H₁₁)2PCH₂CH₂NHCH₂CH₂P(C₆H₁₁)2] 
• 1421448-03-4 C₂₈H₅₃BrNNiP₂⁽¹⁺⁾*Br^(1-) 
• 1421448-08-9 C₂₉H₅₆NNiP₂⁽¹⁺⁾*C₂₄H₂₀B^(1-) 
• 1421448-10-3 C₃₆H₆₉NNiP₂⁽¹⁺⁾*F₆P^(1-) 
• 1421448-13-6 C₂₈H₅₂BrNNiP₂ 
• 1421448-14-7 C₂₉H₅₅NNiP₂ 
• 1421448-05-6 [NiH(bis[2-(dicyclohexylphosphanyl)ethyl]amine)]B(C₆H₅)4 
• 1421448-06-7 [NiH(bis[2-(dicyclohexylphosphanyl)ethyl]amine^(1-))] 
• 1421448-15-8 [NiH(bis[2-(dicyclohexylphosphanyl)ethyl]amine)]PF₆ 
• 1421060-11-8 carbonyl chlorohydride{bis[2-(dicyclohexylphosphino)ethyl]amine}ruthenium(II) 
• 1421448-10-3 C₃₆H₇₀NNiP₂⁽¹⁺⁾*F₆P^(1-) 
• 1553932-11-8 C₂₉H₅₃Cl₂FeNOP₂ 
• 1418299-84-9 (bis[(2-dicyclohexylphosphino)ethyl]amine)cobalt(II)(CH₂SiMe₃) 

Relevant articles and documents

Iron-Catalyzed Alkylation of Nitriles with Alcohols

A general, efficient iron-catalyzed α-alkylation of nitriles with primary alcohols through a hydrogen-borrowing pathway has been developed, allowing a wide variety of alkylated nitriles to be readily accessible. Detailed mechanistic studies suggest that the reaction proceeds via an olefin intermediate with the turnover rate limited by the hydrogenation of the olefin with an iron hydride. Apart from participating in the alkylation, the nitrile is found to play an important role in promoting the formation of and stabilizing the active catalytic species.

Selective Hydrogenation of Amides to Amines and Alcohols Catalyzed by Improved Iron Pincer Complexes

A comparative study on the synthesis, stability, and catalytic activity of various iron pincer complexes with the general formula [(R-PNHP)Fe(H) (CO) (BH4)] is reported, where R denotes the substituent of the terminal PR2-groups (R = tBu, Cy, iPr, Ph, Et). By the example of the synthesized precatalysts, it is shown that the nature of the ligands has a surprising influence on the catalytic properties of the complexes. Bulky ligands and less electron donating ligands affect the stability of the complexes, which preferably react under the loss of CO or H2 to deactivated products. In return, the reduced steric demand and the strong σ-donating properties of the Et-substituted precatalyst (2a) lead to an improved activity in the hydrogenation of esters to alcohols, compared to that of the previously reported iPr-substituted complexes. The improved activity of complex 2a is clearly demonstrated in the direct hydrogenation of amides to alcohols and amines under mild conditions.