825-70-7

Basic information

• Product Name: 5-fluoro-2,3-dihydro-2-Methyl-1H-Indole
• Synonyms: 5-fluoro-2,3-dihydro-2-Methyl-1H-Indole;5-Fluoro-2-Methylindoline
• CAS NO: 825-70-7
• Molecular Formula: C9H10FN
• Molecular Weight: 151.1808032
• Mol File: 825-70-7.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 225-227 °C
• Appearance: /
• Density: 1.089±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• PKA: 5.26±0.40(Predicted)
• CAS DataBase Reference: 5-fluoro-2,3-dihydro-2-Methyl-1H-Indole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-fluoro-2,3-dihydro-2-Methyl-1H-Indole(825-70-7)
• EPA Substance Registry System: 5-fluoro-2,3-dihydro-2-Methyl-1H-Indole(825-70-7)

Safety Data

• Hazardous Substances Data: 825-70-7(Hazardous Substances Data)

Usage

General Description

5-Fluoro-2,3-dihydro-2-Methyl-1H-Indole is a chemical compound with a fluorine atom attached to a dihydro-2-Methyl-1H-Indole core. It is a white to off-white solid with a molecular formula C9H10FIN and a molecular weight of 261.08 g/mol. 5-fluoro-2,3-dihydro-2-Methyl-1H-Indole may be used in various research and industrial applications, including pharmaceuticals, agrochemicals, and materials science. Its specific properties and potential uses are subject to ongoing research and development.

Upstream product

• 83164-79-8 N-allyl-4-fluoroaniline 
• 267002-55-1 2-allyl-4-fluorophenylamine 
• 399-72-4 5-fluoro-2-methyl-1H-indole 
• 371-40-4 4-fluoroaniline 

Relevant articles and documents

METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND, AND NOVEL METAL-DIAMINE COMPLEX

The present invention pertains to a method for producing an optically active compound which includes a step for reducing an imino group of an imine compound or a step for reducing an unsaturated bond of a heterocyclic compound, while in the presence of hydrogen gas as a hydrogen donor and one or more types of complexes selected from a group consisting of a complex represented by general formula (1), a complex represented by general formula (2), a complex represented by general formula (3), and a complex represented by general formula (4) (the general formulas (1)-(4) are as stipulated by claim 1).

NOVEL PYRIMIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL USE THEREOF AS AKT(PKB) PHOSPHORYLATION INHIBITORS

The present invention relates to novel chemical compounds derived from pyrimidines, to the method for preparing same, to the novel intermediates obtained, to the use thereof as drugs, to the pharmaceutical compositions containing same, and to the therapeutic use thereof as AKT inhibitors.

Chemoenzymatic preparation of optically active secondary amines: a new efficient route to enantiomerically pure indolines

An efficient chemoenzymatic route for the synthesis of optically active substituted indolines has been developed. Different lipases have been tested in the alkoxycarbonylation of these secondary amines, Candida antarctica lipase A (CAL-A) was found to be the best biocatalyst for 2-substituted-indolines, and C. antarctica lipase B (CAL-B) for 3-methylindoline. The combination of lipases with a variety of allyl carbonates and tert-butyl methyl ether (TBME) as solvent has allowed the isolation of the carbamate and amine derivatives with a high level of enantiopurity.