82543-18-8

Basic information

• Product Name: 3β,5β-Dihydroxy Drospirenone Ring-opened Alcohol IMpurity
• Synonyms: 3β,5β-Dihydroxy Drospirenone Ring-opened Alcohol IMpurity
• CAS NO: 82543-18-8
• Molecular Formula: C₂₄H₃₈O₄
• Molecular Weight: 390.55612
• Product Categories: Pharmaceuticals, Intermediates & Fine Chemicals, Steroids
• Mol File: 82543-18-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 545.9±50.0 °C(Predicted)
• Appearance: /
• Density: 1.270±0.06 g/cm3(Predicted)
• Vapor Pressure: 0.001Pa at 25℃
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.54±0.70(Predicted)
• CAS DataBase Reference: 3β,5β-Dihydroxy Drospirenone Ring-opened Alcohol IMpurity(CAS DataBase Reference)
• NIST Chemistry Reference: 3β,5β-Dihydroxy Drospirenone Ring-opened Alcohol IMpurity(82543-18-8)
• EPA Substance Registry System: 3β,5β-Dihydroxy Drospirenone Ring-opened Alcohol IMpurity(82543-18-8)

Safety Data

• Hazardous Substances Data: 82543-18-8(Hazardous Substances Data)

Usage

Chemical Properties

Off-white Foam

Upstream product

• 82543-17-7 17α-(3-hydroxy-1-propinyl)-6β,7β;15β,16β-dimethylene-5β-androstane-3β,5,17β-triol 
• 82543-09-7 7β-hydroxy-15β,16β-methylene-3β-pivaloyloxy-5-androsten-17-one 

Downstream Products

• 90457-65-1 dihydrospirorenone 
• 74220-07-8 Spirorenone 
• 197721-70-3 5β-hydroxy-3-carbonyl-6β,7β,5β,16β-dimethylene-17α-pregna-21,17-carboxylactone 

Relevant articles and documents

A drospirenone and intermediate preparation method (by machine translation)

The invention discloses a drospirenone and intermediate preparation method. Preparation method of this invention comprises the following steps: in the solvent, the compound 3 with hydrogen peroxide oxidation reaction shown below, to obtain compound 4 can be. Preparation method of this invention does not use a heavy metal reagent, reduces the toxicity of the preparation process, the use of the reagent are all conventional reagent, low cost, and is favorable for industrial large-scale production. (by machine translation)

Process for the preparation of drospirenone

A process is described for preparing drospirenone, a synthetic steroid with progestogenic, antimineralocorticoid and antiandrogenic activity, useful for the preparation of pharmaceutical compositions with contraceptive action, starting from 5,6beta-epoxy-7beta-hydroxy-15beta,16beta-methylene-3beta-pivaloyloxy-5beta-androstan-17-one.

Synthese von Spirorenon, einem neuen stark wirksamen Aldosteron-Antagonisten

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